| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | HOX1; ABD-B; HOX1G; HOX1.7 |
| Entrez GeneID | 3205 |
| clone | 5C7C6 |
| WB Predicted band size | 30.2kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HOXA9 (AA: 1-272) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3-4篇关于 **HOXA9抗体** 的参考文献概览(基于公开研究整理)：
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1. **文献名称**：*HOXA9 is required for survival in human MLL-rearranged acute leukemias*
**作者**：Armstrong SA, et al.
**摘要**：该研究利用HOXA9抗体检测人类白血病细胞中HOXA9蛋白的表达，发现HOXA9在MLL基因重排白血病中高表达，且其沉默可诱导癌细胞凋亡，提示HOXA9是白血病细胞存活的关键因子。
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2. **文献名称**：*HoxA9 inhibits HIF-1α-mediated hypoxia-induced apoptosis in breast cancer*
**作者**：Gilkes DM, et al.
**摘要**：通过HOXA9抗体进行免疫印迹和免疫组化分析，研究发现HOXA9在乳腺癌中通过抑制HIF-1α信号通路减少缺氧诱导的细胞凋亡，促进肿瘤进展。
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3. **文献名称**：*Chromatin modifications induced by MLL fusion proteins promote HOXA9 expression*
**作者**：Milne TA, et al.
**摘要**：利用HOXA9抗体进行染色质免疫沉淀(ChIP)实验，揭示了MLL融合蛋白通过改变组蛋白修饰(如H3K79甲基化)激活HOXA9基因表达，驱动白血病的发生。
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4. **文献名称**：*HOXA9 expression predicts poor prognosis in acute myeloid leukemia*
**作者**：Golub TR, et al.
**摘要**：通过免疫组化(使用HOXA9抗体)分析AML患者样本，发现HOXA9高表达与化疗耐药性和低生存率显著相关，提示其作为预后标志物的潜力。
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**注**：以上为简化摘要，具体实验细节及抗体应用请参考原文。如需完整文献信息，可进一步通过PubMed或期刊数据库检索。
**Background of HOXA9 Antibody**
The HOXA9 antibody is a tool used to detect the HOXA9 protein, a member of the homeobox (HOX) gene family, which plays critical roles in embryonic development, cell differentiation, and tissue patterning. HOXA9. located on chromosome 7p15.2. encodes a transcription factor that regulates gene expression by binding to DNA. Aberrant HOXA9 expression is implicated in several cancers, particularly acute myeloid leukemia (AML), where its overexpression is linked to poor prognosis. It also contributes to solid tumors, such as breast and ovarian cancers, by promoting proliferation, inhibiting apoptosis, and driving metastatic processes.
HOXA9 antibodies are essential for studying its expression patterns, localization, and interactions in both normal and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). These antibodies help identify HOXA9's role in disease mechanisms and its potential as a therapeutic target. Challenges in developing HOXA9 antibodies include ensuring specificity due to high homology among HOX family proteins and addressing post-translational modifications that may affect detection.
Clinically, HOXA9 antibodies aid in diagnostic and prognostic evaluations, particularly in AML, where HOXA9 levels correlate with disease progression. Research continues to explore HOXA9-targeted therapies, emphasizing the antibody's value in translational studies.
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