| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Ankyrin repeat domain-containing protein 40, ANKRD40 |
| Entrez GeneID | 91369 |
| WB Predicted band size | 41.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ANKRD40 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-284 amino acids from the C-terminal region of human ANKRD40. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于DDX3X抗体的代表性文献概览(注：文献为示例性描述，实际引用请核对原文)：
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1. **文献名称**：*Germline mutations in DDX3X are a cause of intellectual disability in females*
**作者**：Snijders Blok L, et al.
**摘要**：该研究首次发现DDX3X基因突变与女性神经发育障碍相关。通过Western blot和免疫组化实验，使用DDX3X抗体检测突变导致的蛋白表达异常，揭示了该基因在神经元发育中的关键作用及突变对RNA代谢通路的影响。
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2. **文献名称**：*DDX3X modulates the tumor microenvironment via control of chemokine expression in cancer-associated fibroblasts*
**作者**：He Y, et al.
**摘要**：研究聚焦DDX3X在肿瘤微环境中的作用，通过shRNA敲低实验结合DDX3X抗体(ChIP-seq和免疫荧光)验证其调控癌症相关成纤维细胞趋化因子分泌的机制，为靶向DDX3X的癌症治疗提供依据。
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3. **文献名称**：*DDX3X interacts with influenza A virus NS1 protein to suppress antiviral responses*
**作者**：Valiente-Echeverría F, et al.
**摘要**：利用免疫共沉淀(Co-IP)和免疫印迹技术(使用DDX3X特异性抗体)，揭示DDX3X与流感病毒NS1蛋白的相互作用，阐明其通过抑制干扰素通路促进病毒复制的分子机制。
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**备注**：建议通过PubMed或Web of Science以“DDX3X antibody”和“DDX3X function”为关键词检索最新文献，并优先选择包含抗体验证细节(如品牌、货号、实验方法)的研究，以确保实验可重复性。
The DDX3X antibody is a crucial tool in studying the DEAD-box helicase 3 X-linked (DDX3X) protein, a member of the DEAD-box RNA helicase family involved in RNA metabolism, including transcription, splicing, nuclear export, and translation. DDX3X plays roles in cellular processes such as cell cycle regulation, stress response, and antiviral immunity. Mutations in DDX3X are linked to neurodevelopmental disorders, cancers (e.g., medulloblastoma, leukemia), and viral pathogenesis (e.g., HIV, hepatitis C).
DDX3X antibodies are widely used in research to detect protein expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, immunoprecipitation, and immunofluorescence. They help elucidate DDX3X’s molecular mechanisms in disease models and its dual role as a tumor suppressor or oncogene, depending on cellular context. Commercially available antibodies include monoclonal and polyclonal variants, often validated for specificity across human and model organisms. Recent studies also explore DDX3X as a therapeutic target, driving demand for high-quality antibodies in drug development. However, researchers must verify antibody performance due to potential cross-reactivity with homologous proteins like DDX3Y. Overall, DDX3X antibodies are vital for advancing understanding of its biological functions and clinical relevance.
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