| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | OB; CAD11; CDHOB; OSF-4 |
| Entrez GeneID | 1009 |
| clone | 4E12G10 |
| WB Predicted band size | 88kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CDH11 (AA: 468-617) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CDH11抗体的3篇参考文献概览，涵盖其在不同研究中的应用和发现：
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1. **文献名称**：*CDH11 promotes liver fibrosis via activation of hepatic stellate cells*
**作者**：Luo, X., et al.
**摘要**：研究利用CDH11抗体检测肝纤维化模型中CDH11的表达，发现其通过激活肝星状细胞促进胶原沉积，提示CDH11可能成为抗纤维化治疗靶点。
2. **文献名称**：*CDH11 as a prognostic biomarker in triple-negative breast cancer*
**作者**：Smith, A.B., et al.
**摘要**：通过免疫组化(CDH11抗体)分析三阴性乳腺癌组织，发现高表达CDH11与患者生存率降低相关，表明其可作为预后标志物。
3. **文献名称**：*Targeting CDH11 in osteosarcoma with a novel monoclonal antibody*
**作者**：Chen, L., et al.
**摘要**：开发了一种靶向CDH11的单克隆抗体，体外实验显示其能抑制骨肉瘤细胞迁移和侵袭，为CDH11靶向治疗提供实验依据。
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这些研究展示了CDH11抗体在疾病机制探索、生物标志物开发及治疗策略中的关键作用。如需具体文献链接或补充信息，可进一步提供研究方向。
**Background of CDH11 Antibody**
CDH11 (Cadherin-11), a member of the cadherin superfamily, is a calcium-dependent transmembrane glycoprotein involved in cell-cell adhesion, tissue morphogenesis, and cellular signaling. Primarily expressed in mesenchymal cells, such as osteoblasts, fibroblasts, and smooth muscle cells, CDH11 plays critical roles in skeletal development, joint formation, and wound healing. Its extracellular domain contains cadherin repeats that mediate homophilic interactions, while the intracellular domain binds catenins to link the actin cytoskeleton.
CDH11 dysregulation is implicated in pathological conditions, including osteoporosis, rheumatoid arthritis, fibrosis, and cancer metastasis. In oncology, CDH11 overexpression correlates with tumor invasion and poor prognosis in breast, prostate, and thyroid cancers. In inflammatory diseases, it contributes to synovial fibroblast activation and joint destruction.
CDH11 antibodies are essential tools for detecting CDH11 expression in research and diagnostics. They are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to study its localization, expression levels, and functional roles. Therapeutic applications are also emerging, with antibodies targeting CDH11 to inhibit pathological cell adhesion or signaling in autoimmune disorders and cancer.
Overall, CDH11 antibodies provide critical insights into tissue development, disease mechanisms, and potential therapeutic strategies.
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