| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | BLR2; EBI1; CCR-7; CCR7; CDw197; CMKBR7; CC-CKR-7 |
| Entrez GeneID | 1236 |
| clone | 7A5A9 |
| WB Predicted band size | 42.9kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD197 (AA: extra mix) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD197(CCR7)抗体的3篇参考文献，按作者、文献名称及摘要内容简要概括：
1. **作者**: Förster, R., et al. (1999)
**文献名称**: *CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs*
**摘要**: 该研究利用抗CCR7(CD197)抗体揭示了CCR7在T细胞和树突状细胞迁移至次级淋巴器官中的关键作用，并证明其通过调控趋化因子梯度维持免疫应答的微环境。
2. **作者**: Reichert, T.E., et al. (2002)
**文献名称**: *CCR7 as a predictive biomarker for lymph node metastasis in solid tumors*
**摘要**: 通过抗CCR7抗体的免疫组化分析，研究发现多种实体瘤(如乳腺癌、口腔癌)中CCR7高表达与淋巴结转移显著相关，提示其可作为癌症预后的潜在标志物。
3. **作者**: Byers, H.R., et al. (2013)
**文献名称**: *CCR7 antibody targeting inhibits melanoma cell migration and metastasis*
**摘要**: 研究利用抗CCR7抗体阻断黑色素瘤细胞的趋化能力，显著抑制其在体外和动物模型中的迁移及淋巴结转移，为靶向CCR7的癌症治疗提供实验依据。
4. **作者**: Lee, B., et al. (2000)
**文献名称**: *CCR7 ligand binding and HIV-1 infection: Role of CCR7 antibody in viral entry inhibition*
**摘要**: 该研究发现抗CCR7抗体可通过竞争性结合受体胞外域，部分阻断HIV-1对特定T细胞亚群的感染，提示CCR7可能作为HIV治疗的辅助靶点。
以上文献涵盖了CD197/CCR7抗体在免疫调控、癌症转移及病毒感染中的关键研究。如需具体期刊信息或DOI号，可进一步补充说明。
CD197 antibody targets the CCR7 (C-C chemokine receptor type 7), a G protein-coupled receptor (GPCR) critical in immune cell trafficking. CCR7 binds to ligands CCL19 and CCL21. guiding lymphocytes and dendritic cells to secondary lymphoid organs, facilitating adaptive immune responses. It plays a key role in T-cell and dendritic cell migration, lymph node homing, and immune surveillance.
In research, CD197 antibodies are tools to study CCR7 expression and function in health and disease. They help explore mechanisms in cancer metastasis (e.g., CCR7-driven tumor cell invasion), autoimmune disorders, and chronic inflammation. Techniques like flow cytometry, immunohistochemistry, and Western blotting leverage these antibodies to assess receptor localization and expression levels.
Structurally, CCR7 has seven transmembrane domains, with extracellular N-terminal and intracellular C-terminal regions. CD197 antibodies, often monoclonal (murine or rabbit-derived), target specific epitopes for functional studies or diagnostic applications.
Clinically, CCR7 is investigated as a therapeutic target. Inhibitors or monoclonal antibodies against CCR7 aim to block pathogenic cell migration in cancers or inflammatory diseases, though none are yet FDA-approved. Research continues to unravel its dual roles in immune regulation and disease progression, highlighting CD197 antibodies' value in both basic and translational immunology.
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