| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | NEP; SFE; MME; CALLA; CMT2T; SCA43 |
| Entrez GeneID | 4311 |
| clone | 3G6B11 |
| WB Predicted band size | 85.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD10 (AA: extra 549-750) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD10抗体的3篇参考文献示例(注：文献信息为示例性内容，实际引用需核对真实文献)：
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1. **文献名称**: *CD10/neutral endopeptidase 24.11 in tumorigenesis: Role in cancer and immune modulation*
**作者**: Shipp MA et al.
**摘要**: 该综述讨论了CD10作为中性内肽酶的生物学功能，及其在白血病、乳腺癌等肿瘤中的表达模式。研究强调了CD10在调控细胞信号(如缓激肽和神经肽)中的作用及其与肿瘤侵袭性的关联。
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2. **文献名称**: *CD10 expression in diffuse large B-cell lymphoma: A potential marker for prognosis and targeted therapy*
**作者**: Li Y et al.
**摘要**: 本研究通过免疫组化分析发现，CD10在弥漫大B细胞淋巴瘤(DLBCL)中的表达与患者预后显著相关，提示CD10可能作为生物标志物用于指导靶向治疗或化疗方案选择。
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3. **文献名称**: *CD10-negative and CD10-positive immature B-cell populations in normal human bone marrow*
**作者**: LeBien TW et al.
**摘要**: 该文献通过流式细胞术分析了正常骨髓中B细胞前体的CD10表达差异，揭示了CD10在B细胞发育阶段的分化标志作用，为白血病分型提供了理论基础。
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4. **文献名称**: *CD10-directed CAR-T cell therapy for acute myeloid leukemia: Preclinical evaluation*
**作者**: Smith R et al.
**摘要**: 实验研究探索了靶向CD10的CAR-T细胞在急性髓系白血病(AML)模型中的疗效，结果显示其可特异性清除CD10阳性肿瘤细胞，为新型免疫疗法开发提供依据。
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如需具体文献，建议通过PubMed或Google Scholar以“CD10 antibody”、“CD10 cancer”或“CD10 biomarker”为关键词检索近年研究。
CD10 antibody targets the CD10 antigen, also known as neutral endopeptidase (NEP) or common acute lymphoblastic leukemia antigen (CALLA). CD10 is a 90-110 kDa cell surface glycoprotein belonging to the zinc-dependent metalloprotease family. It plays a role in cleaving peptide hormones, including enkephalins, endothelin, and bradykinin, thereby regulating cellular signaling and inflammatory responses.
Initially identified in acute lymphoblastic leukemia (ALL), CD10 is widely expressed in hematopoietic and non-hematopoietic tissues. In normal physiology, it is found on lymphoid progenitors, germinal center B-cells, granulocytes, and epithelial cells of organs like the kidney, intestine, and placenta. Its expression pattern makes it a valuable marker in diagnostic pathology.
Clinically, CD10 antibodies are essential in classifying hematologic malignancies. They help distinguish B-cell ALL subtypes, follicular lymphoma, and Burkitt lymphoma. In non-lymphoid contexts, CD10 expression correlates with tumor aggressiveness in breast cancer, melanoma, and renal cell carcinoma.
Research applications include studying CD10's role in tumor progression, immune modulation, and its potential as a therapeutic target. Inhibitors of CD10 enzymatic activity are explored for conditions like heart failure and chronic pain. However, its dual role as both a tumor suppressor and promoter in different contexts remains an active area of investigation.
Overall, CD10 antibodies serve as crucial tools in diagnostics, research, and emerging therapeutic strategies.
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