Mouse Monoclonal CD207 Antibody

CD207 antibody targets the CD207 antigen, a C-type lectin receptor encoded by the *CD207* gene, also known as Langerin. Primarily expressed on Langerhans cells (LCs), a subset of dendritic cells in epithelial tissues like skin and mucosa, CD207 plays a critical role in pathogen recognition and immune surveillance. It binds carbohydrate structures on microbes, facilitating antigen uptake via Birbeck granules—unique organelles in LCs involved in processing and presenting antigens to T cells. This interaction is vital for initiating adaptive immune responses against pathogens, including HIV, HPV, and fungi. CD207's specificity for LCs makes it a valuable marker for identifying these cells in research and diagnostics. Antibodies against CD207 are widely used in immunohistochemistry and flow cytometry to study LC distribution, function, and involvement in diseases such as Langerhans cell histiocytosis, inflammatory skin disorders, and infections. Additionally, CD207 antibodies aid in exploring LC roles in cancer immunity and mucosal immunity, offering insights into therapeutic targeting. Their application extends to understanding mechanisms of antigen cross-presentation and tolerance, highlighting CD207's dual role in immune activation and regulation. Overall, CD207 antibodies are essential tools in immunology and dermatology research, bridging structural biology with clinical pathology.