Mouse Monoclonal GRM2 Antibody

The GRM2 antibody targets the metabotropic glutamate receptor 2 (mGluR2), a G protein-coupled receptor (GPCR) primarily expressed in the central nervous system. mGluR2. encoded by the GRM2 gene, regulates glutamate neurotransmission by inhibiting adenylyl cyclase activity via Gi/o protein coupling. It plays a critical role in modulating synaptic plasticity, neurodevelopment, and cognitive functions. Dysregulation of mGluR2 is implicated in neurological and psychiatric disorders, including anxiety, schizophrenia, and Parkinson’s disease. GRM2 antibodies are essential tools for studying receptor localization, expression levels, and signaling mechanisms in research models. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate mGluR2’s role in health and disease. Recent therapeutic strategies, such as mGluR2-positive allosteric modulators, highlight its potential as a drug target. However, antibody specificity remains a challenge due to homology among mGluR subtypes. Validated GRM2 antibodies enable precise detection, aiding mechanistic studies and the development of targeted therapies for CNS disorders.