| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ITGB4; GP150 |
| Entrez GeneID | 3691 |
| clone | 1D6B4 |
| WB Predicted band size | 202.2kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD104 (AA: extra 29-206) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD104(整合素β4.ITGB4)抗体的3篇代表性文献概览：
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1. **文献名称**：*Integrin β4 is required for hemidesmosome formation and cell polarity in the developing epidermis*
**作者**：Dowling J, et al.
**摘要**：研究通过基因敲除小鼠模型揭示，整合素β4(CD104)对表皮半桥粒的形成至关重要，其缺失导致细胞极性紊乱和皮肤水疱表型，强调了CD104在上皮组织完整性中的作用。
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2. **文献名称**：*The α6β4 integrin in cancer: Metastasis and beyond*
**作者**：Mercurio AM, et al.
**摘要**：综述了α6β4整合素(CD104为β4亚基)在肿瘤侵袭和转移中的双重作用，探讨其通过调控细胞迁移、存活信号通路(如PI3K/AKT)促进癌症进展的机制。
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3. **文献名称**：*Targeting integrin β4 for cancer therapy: Current insights and future directions*
**作者**：Giancotti FG, et al.
**摘要**：提出整合素β4(CD104)作为治疗靶点的潜力，分析其抗体在抑制肿瘤生长和转移中的实验效果，并讨论其与生长因子受体(如EGFR)的协同信号传导机制。
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这些文献覆盖了CD104在基础生物学、病理机制及治疗应用中的关键研究，可为进一步实验设计或综述提供参考。如需具体实验抗体信息，建议补充筛选条件(如物种来源、应用场景)。
CD104. also known as integrin β4. is a transmembrane protein subunit that pairs with α6 integrin to form the α6β4 heterodimer, a key component of hemidesmosomes. These structures anchor epithelial cells to the basement membrane by binding laminins, ensuring tissue integrity. Unlike other integrin β subunits, β4 contains a uniquely long cytoplasmic domain with signaling motifs that regulate cell adhesion, migration, and survival.
CD104 antibodies specifically target this subunit, enabling researchers to study its expression and function. In research, these antibodies are used in techniques like flow cytometry, immunofluorescence, and Western blotting to investigate β4's role in epithelial homeostasis, wound healing, and cancer progression. Dysregulation of α6β4 is linked to aggressive tumor behavior, including invasion and metastasis in carcinomas (e.g., breast, lung).
Clinically, CD104 antibodies aid in diagnosing genetic disorders like epidermolysis bullosa, where β4 mutations cause skin fragility. They also help characterize tumors with aberrant β4 expression, potentially guiding therapeutic strategies. Recent studies explore β4's signaling crosstalk with growth factor receptors, highlighting its dual role as an adhesive molecule and signaling hub.
Overall, CD104 antibodies remain vital tools for unraveling the complex biology of integrin β4 in health and disease.
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