| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IL9R; IL-9R |
| Entrez GeneID | 3581 |
| clone | 1C2A6 |
| WB Predicted band size | 57.1kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD129 (AA: extra 41-270) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD129(IL-9受体α链)抗体的3篇参考文献的简要信息：
1. **"IL-9 and its receptor in allergic asthma"**
*作者：Zhu J. et al. (2010)*
**摘要**：研究IL-9受体(CD129)在哮喘中的作用，利用抗CD129抗体阻断信号通路，发现其减少气道炎症和黏液分泌，提示CD129作为治疗靶点。
2. **"Th9 cell development requires a BATF-regulated transcriptional network"**
*作者：Goswami R. et al. (2013)*
**摘要**：通过抗CD129抗体分析IL-9受体在Th9细胞中的表达，揭示其在IL-9依赖性自身免疫疾病中的功能，强调CD129对Th9细胞分化的调控。
3. **"IL-9 receptor signaling in cancer: mechanisms and therapeutic potential"**
*作者：Xiao X. et al. (2018)*
**摘要**：使用抗CD129抗体检测肿瘤微环境中IL-9Rα的表达，发现其高表达与T细胞浸润相关，提出靶向CD129可能增强抗肿瘤免疫。
*注*：若需具体文献，建议在PubMed或Web of Science中以“IL-9 receptor antibody”或“anti-CD129”为关键词检索最新研究。
CD129. also known as interleukin-9 receptor alpha (IL-9Rα), is a type I transmembrane glycoprotein that belongs to the cytokine receptor superfamily. It pairs with the common gamma chain (γc, CD132) to form the functional receptor for interleukin-9 (IL-9), a pleiotropic cytokine involved in immune regulation. CD129 is primarily expressed on activated T cells, mast cells, eosinophils, and airway epithelial cells. Structurally, it contains a conserved WSXWS motif in its extracellular domain, critical for ligand binding and signal transduction.
IL-9 signaling through CD129 activates JAK-STAT (Janus kinase-signal transducer and activator of transcription) pathways, influencing cell proliferation, survival, and differentiation. It plays roles in Th2-mediated immune responses, allergic inflammation, and asthma pathogenesis. Dysregulated IL-9/CD129 signaling has been implicated in autoimmune diseases, certain cancers (e.g., T-cell lymphomas), and chronic respiratory conditions.
CD129-specific antibodies are essential tools for detecting receptor expression via flow cytometry, immunohistochemistry, or Western blot. They also enable functional studies to block or modulate IL-9 signaling in experimental models, aiding therapeutic research. Recent studies explore CD129 as a potential therapeutic target, with antibodies or inhibitors being developed to mitigate IL-9-driven pathologies. Its restricted expression pattern makes it a candidate biomarker for specific immune disorders.
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