| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ICAM2 |
| Entrez GeneID | 3384 |
| clone | 6B9G10 |
| WB Predicted band size | 30.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD102 (AA: extra 25-223) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD102(ICAM-2)抗体的3篇代表性文献示例(内容为模拟概括，具体文献需根据实际检索确认)：
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1. **文献名称**：*ICAM-2 regulates vascular permeability and leukocyte transmigration in inflammation*
**作者**：Dustin, M.L., Springer, T.A.
**摘要**：研究通过CD102抗体阻断实验，揭示了ICAM-2在内皮细胞中调控白细胞跨膜迁移的作用，并证明其缺失会加剧血管通透性异常和炎症反应。
2. **文献名称**：*Structural and functional characterization of CD102 in T cell adhesion*
**作者**：Gahmberg, C.G., et al.
**摘要**：利用CD102特异性抗体，阐明了ICAM-2与淋巴细胞表面配体的相互作用机制，证实其在免疫突触形成和T细胞活化中的关键功能。
3. **文献名称**：*CD102 antibody targeting inhibits tumor angiogenesis in murine models*
**作者**：Lu, H., et al.
**摘要**：通过抗CD102抗体靶向肿瘤血管内皮细胞，抑制ICAM-2介导的血管生成信号通路，显著降低实体瘤的微血管密度和转移潜能。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“CD102 antibody”“ICAM-2 therapeutic”等获取最新研究。
CD102. also known as intercellular adhesion molecule-2 (ICAM-2), is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is constitutively expressed on endothelial cells, platelets, and certain immune cells, playing a critical role in leukocyte trafficking and endothelial cell interactions. CD102 mediates cell adhesion by binding to lymphocyte function-associated antigen-1 (LFA-1. αLβ2 integrin) on leukocytes, facilitating immune cell recruitment during inflammation and immune surveillance.
CD102 antibodies are tools developed to target this molecule for research or therapeutic purposes. They are widely used to study leukocyte-endothelial interactions in inflammatory diseases, atherosclerosis, and cancer metastasis. In experimental settings, anti-CD102 antibodies can block LFA-1 binding to modulate immune responses or visualize vascular and immune cell dynamics. Compared to ICAM-1. CD102 exhibits distinct expression patterns and ligand-binding kinetics, making it particularly relevant in chronic inflammatory processes and hematological homeostasis.
Recent studies explore CD102's role in tumor angiogenesis and its potential as a biomarker. Therapeutic antibodies against CD102 remain investigational but may offer strategies for controlling pathological inflammation or enhancing immunotherapy efficacy. Its dual function in immune regulation and vascular biology continues to drive interest in CD102-targeted research.
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