| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | R1; CD1; CD1A |
| Entrez GeneID | 910 |
| clone | 1D6B7 |
| WB Predicted band size | 37kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD1B (AA: extra 18-303) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD1B抗体的模拟参考文献示例(实际文献需通过学术数据库验证)：
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1. **Title**: "CD1B-restricted T cell responses in microbial immunity"
**Authors**: Porcelli SA, Modlin RL
**Summary**: 探讨CD1B分子在抗微生物免疫中的作用，重点研究CD1B限制性T细胞识别分枝杆菌脂质抗原的机制，并提及相关抗体的实验应用。
2. **Title**: "Monoclonal antibodies specific for human CD1b antigen"
**Authors**: Gumperz JE, et al.
**Summary**: 描述针对人CD1B蛋白的单克隆抗体的开发与表征，验证其在流式细胞术和免疫组织化学中对CD1B+细胞的检测效果。
3. **Title**: "Structural insights into CD1B-lipid antigen presentation"
**Authors**: Bhati M, et al.
**Summary**: 通过X射线晶体学解析CD1B与脂质抗原复合物的结构，使用特异性抗体阐明其抗原结合域的构象变化。
4. **Title**: "CD1B expression in dendritic cells and tuberculosis susceptibility"
**Authors**: Ly D, et al.
**Summary**: 研究CD1B在树突状细胞中的表达与结核病易感性的关联，利用抗CD1B抗体分析患者样本中的蛋白水平差异。
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**注意**：以上为模拟参考文献，实际文献需通过PubMed、Google Scholar等平台以关键词“CD1B antibody”或“CD1B monoclonal antibody”检索获取。建议结合具体研究背景筛选近年高相关性论文。
CD1b antibodies target the CD1b protein, a member of the CD1 family of antigen-presenting molecules. CD1 molecules are structurally related to MHC class I proteins but specialize in binding lipid-based antigens rather than peptides. CD1b is primarily expressed on professional antigen-presenting cells, such as dendritic cells and B cells, and plays a critical role in immune surveillance by presenting lipid antigens derived from pathogens or self-tissues to specific T cells, particularly invariant natural killer T (iNKT) cells and lipid-reactive αβ T cells.
CD1b is notable for its deep, hydrophobic antigen-binding groove, which accommodates long alkyl chains of microbial lipids, such as those from *Mycobacterium tuberculosis*. This makes CD1b crucial in immune responses against mycobacterial infections. Antibodies against CD1b are valuable tools in research and diagnostics. They help visualize CD1b expression in tissues, study its intracellular trafficking, and investigate its interaction with lipids or T-cell receptors.
In clinical contexts, CD1b dysregulation has been linked to autoimmune diseases and cancer. Anti-CD1b antibodies may aid in characterizing CD1b-related immune dysfunction or developing targeted therapies. However, therapeutic applications remain exploratory, focusing on modulating lipid antigen presentation to enhance anti-infective or anti-tumor immunity. Overall, CD1b antibodies serve as essential reagents for deciphering lipid-specific immune mechanisms and potential translational avenues.
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