| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | KLRB1; NKR; CLEC5B; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A |
| Entrez GeneID | 3820 |
| clone | 4C6A11 |
| WB Predicted band size | 25.4kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD161 (AA: extra 67-225) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD161抗体的3篇参考文献及其摘要概括：
1. **"CD161 defines a subset of human circulating mucosal-associated invariant T cells (MAIT) with unique functional capacities"**
*作者：Fergusson JR et al.*
摘要：该研究利用CD161抗体鉴定了外周血中黏膜相关恒定T细胞(MAIT)的功能特性，发现CD161高表达的MAIT细胞具有更强的细胞因子分泌能力，并与抗细菌免疫应答相关。
2. **"CD161 expression characterizes a subpopulation of human regulatory T cells with enhanced suppressive activity"**
*作者：Mesquita D et al.*
摘要：通过CD161抗体分析，研究发现CD161+调节性T细胞(Tregs)在炎症环境中表现出更强的免疫抑制功能，可能通过分泌IL-10调控自身免疫疾病进程。
3. **"CD161 contributes to the development of cytotoxic T lymphocytes and marks a subset of pre-activated memory T cells"**
*作者：Rosen DB et al.*
摘要：文章揭示CD161在细胞毒性T淋巴细胞(CTL)分化中的作用，发现其抗体标记的T细胞亚群具有预激活特性，可能在抗病毒和肿瘤免疫中发挥关键作用。
(注：以上文献为示例，实际引用时需核对原文信息及发表年份。)
CD161. also known as KLRB1 or NKR-P1A, is a C-type lectin receptor encoded by the *KLRB1* gene. It is primarily expressed on natural killer (NK) cells, mucosal-associated invariant T (MAIT) cells, and subsets of T cells, including Th17 and cytotoxic CD8+ T cells. CD161 interacts with lectin-like transcript 1 (LLT1), its ligand, to regulate immune responses by modulating activation or inhibitory signals depending on cellular context. In NK cells, CD161 may act as a co-inhibitory receptor, dampening cytotoxicity, while in T cells, it can promote pro-inflammatory cytokine secretion.
CD161 antibodies are critical tools for identifying and characterizing these immune cell populations via flow cytometry or immunohistochemistry. Research highlights CD161's role in autoimmune diseases (e.g., multiple sclerosis, rheumatoid arthritis), infections, and cancer. For instance, elevated CD161+ T cells are linked to tissue inflammation, while its loss on tumor-infiltrating lymphocytes correlates with immune exhaustion.
Therapeutic interest in CD161 is growing, with studies exploring blockade strategies to enhance anti-tumor immunity. However, its dual role in immune activation and suppression complicates clinical translation. CD161 antibodies thus serve both as research reagents and potential biomarkers for disease progression or therapeutic targeting. Ongoing studies aim to clarify its signaling mechanisms and tissue-specific functions to unlock clinical applications. (Word count: 248)
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