| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | TR4; TAK1 |
| Entrez GeneID | 7182 |
| clone | 8F2E8 |
| WB Predicted band size | 65.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human NR2C2 (AA: 62-356) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于NR2C2抗体的3篇参考文献示例(内容为模拟虚构，仅供参考)：
1. **"Characterization of a specific polyclonal antibody for nuclear receptor NR2C2 and its application in chromatin immunoprecipitation"**
- **作者**: Zhang L, et al.
- **摘要**: 本研究开发并验证了一种针对人NR2C2蛋白C末端结构域的多克隆抗体，通过Western blot和免疫荧光证实其特异性。该抗体成功应用于染色质免疫沉淀(ChIP)，揭示了NR2C2在肝癌细胞中的靶基因结合位点。
2. **"NR2C2 antibody-based detection of receptor expression in neurodegenerative disease models"**
- **作者**: Gupta R, et al.
- **摘要**: 利用商业NR2C2单克隆抗体分析阿尔茨海默病小鼠模型中受体表达水平的变化，发现其与神经元凋亡通路相关。研究强调了抗体在脑组织切片免疫组化中的高灵敏度和低交叉反应性。
3. **"Validation of anti-NR2C2 for flow cytometry and its role in T-cell differentiation"**
- **作者**: Kim S, et al.
- **摘要**: 通过流式细胞术验证了一种重组NR2C2抗体的适用性，证明其在检测T细胞亚群中NR2C2动态表达的有效性，为研究NR2C2在免疫调控中的作用提供了工具。
如需真实文献，建议通过PubMed或Google Scholar以“NR2C2 antibody validation”“NR2C2 immunolocalization”等关键词检索。
The nuclear receptor subfamily 2 group C member 2 (NR2C2), also known as testicular receptor 4 (TR4), is a transcription factor belonging to the nuclear receptor superfamily. It plays diverse roles in regulating gene expression by binding to specific DNA response elements, either as a monomer, homodimer, or heterodimer with other receptors. NR2C2 is involved in critical biological processes, including embryonic development, metabolism, reproduction, and circadian rhythm regulation. Studies highlight its function in lipid metabolism, glucose homeostasis, and adipocyte differentiation, linking it to metabolic disorders like obesity and diabetes. Additionally, NR2C2 has been implicated in cancer progression, with both tumor-suppressive and oncogenic roles observed in different contexts, such as prostate, liver, and colorectal cancers.
NR2C2 antibodies are essential tools for investigating its expression, localization, and molecular interactions in research. They are widely used in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to study NR2C2's regulatory mechanisms in health and disease. Commercially available antibodies are typically raised against specific epitopes, such as the N-terminal or ligand-binding domains, and require validation for specificity and cross-reactivity. Research utilizing NR2C2 antibodies continues to uncover its therapeutic potential, particularly in targeting metabolic syndromes and cancers, though its context-dependent roles necessitate careful functional analysis in different tissues and pathological conditions.
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