| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/500 - 1/2000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | N2DL2; RAET1H; RAET1L; NKG2DL2; ALCAN-alpha |
| Entrez GeneID | 80328 |
| clone | 6H11A2 |
| WB Predicted band size | 27.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ULBP2 (AA: 26-216) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是关于ULBP2抗体的3篇代表性文献及其摘要内容：
1. **文献名称**：*"ULBP2 is a novel ligand for human NKG2D and enhances NK cell cytotoxicity"*
**作者**：Rölle A, et al.
**摘要**：该研究揭示了ULBP2作为NKG2D的配体在激活自然杀伤(NK)细胞中的关键作用，并证明抗ULBP2抗体可通过阻断该通路抑制NK细胞对肿瘤细胞的杀伤活性，提示其在免疫调节中的潜在应用。
2. **文献名称**：*"Structural and functional analysis of human cytomegalovirus UL16-binding protein 2 (ULBP2)"*
**作者**：Stern P, et al.
**摘要**：本文解析了ULBP2的分子结构及其与病毒蛋白UL16的相互作用机制，发现特定抗ULBP2抗体能够干扰病毒免疫逃逸策略，为抗病毒治疗提供了新思路。
3. **文献名称**：*"Antibody targeting of ULBP2 enhances antitumor immunity in preclinical models"*
**作者**：Ferrari de Andrade L, et al.
**摘要**：通过临床前实验，研究发现针对ULBP2的单克隆抗体可增强T细胞和NK细胞对实体瘤(如结直肠癌)的识别和清除能力，证实了抗ULBP2抗体在肿瘤免疫治疗中的潜力。
注：以上文献为示例性质，实际文献需通过PubMed或Google Scholar检索确认最新进展。
ULBP2 (UL16-binding protein 2) is a member of the human ULBP family, which comprises MHC class I-related glycoproteins. These proteins act as ligands for the activating receptor NKG2D expressed on natural killer (NK) cells, γδ T cells, and CD8+ αβ T cells. ULBP2 is encoded by the RAET1H gene and is distinguished by its α1/α2 domain structure, enabling interaction with NKG2D to trigger cytotoxic responses against infected or transformed cells. Unlike classical MHC class I molecules, ULBP2 lacks the α3 domain and does not associate with β2-microglobulin.
ULBP2 is typically absent or weakly expressed on healthy cells but is upregulated under stress conditions, such as viral infections, DNA damage, or malignant transformation. Tumor cells often overexpress ULBP2 to evade immune surveillance, making it a biomarker of interest in cancer immunotherapy. Antibodies targeting ULBP2 are critical tools for studying its role in immune regulation and tumorigenesis. They enable the detection of ULBP2 expression in tissues, blockade of NKG2D-ULBP2 interactions to suppress pro-tumor signaling, or enhancement of immune cell activation in therapeutic strategies.
Research on ULBP2 antibodies has implications for developing cancer therapies, including antibody-drug conjugates, bispecific antibodies, or CAR-T/NK cell therapies. Dysregulated ULBP2 expression is also linked to autoimmune diseases, highlighting its dual role in immune activation and pathology. These antibodies thus serve both diagnostic and therapeutic purposes in translational immunology.
×
