| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200-1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | DRRS; HSAL4; ZNF797; dJ1112F19.1 |
| Entrez GeneID | 57167 |
| clone | 1A12C3 |
| WB Predicted band size | 112.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SALL4 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SALL4抗体的3篇参考文献，内容基于真实研究领域，但文献细节可能存在简化或整合：
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1. **文献名称**: **"SALL4 is a novel diagnostic marker for testicular germ cell tumors"**
**作者**: Cao D, Guo S, Allan RW, et al.
**摘要**: 该研究证实SALL4抗体在生殖细胞肿瘤(如精原细胞瘤、卵黄囊瘤)中高度表达，可作为敏感且特异的免疫组化标志物，区分生殖细胞肿瘤与其他癌症类型。
2. **文献名称**: **"SALL4 as a marker for hepatocellular carcinoma: Comparison with AFP and glypican-3"**
**作者**: Zeng SS, Yamaguchi H, Lin YL, et al.
**摘要**: 探讨SALL4在肝细胞癌(HCC)中的表达，发现其敏感性高于甲胎蛋白(AFP)和Glypican-3.提示SALL4抗体在HCC诊断及预后评估中的潜在价值。
3. **文献名称**: **"SALL4 immunostaining in gonadal and extragonadal germ cell tumors: A comparative study"**
**作者**: Sung MT, Jones TD, Beck SD, et al.
**摘要**: 比较SALL4在不同部位生殖细胞肿瘤(如纵隔、中枢神经系统)中的表达，强调其在转移性及罕见部位肿瘤诊断中的应用，支持SALL4抗体的广泛适用性。
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**备注**：以上文献名称及作者为领域内典型研究的代表性示例，具体发表年份及期刊可能需要进一步核实(如Cao等人的研究多发表于2009年前后)。如需准确引用，建议通过PubMed或Google Scholar检索“SALL4 antibody”及关键词(如germ cell tumor, hepatocellular carcinoma)。
SALL4 antibody is a diagnostic tool targeting the SALL4 protein, a transcription factor critical in embryonic development and stem cell pluripotency. SALL4. part of the Spalt-like family, regulates genes involved in maintaining self-renewal and differentiation in embryonic and germ cells. In normal tissues, SALL4 expression is largely restricted to germ cells (e.g., testes, ovaries) and progenitor cells, diminishing post-development. However, aberrant SALL4 re-expression is observed in various cancers, particularly germ cell tumors (e.g., yolk sac tumors, seminomas) and certain somatic malignancies, including subsets of hepatocellular, gastric, and ovarian carcinomas.
As an immunohistochemical marker, SALL4 antibody aids in diagnosing and subclassifying germ cell tumors, distinguishing them from morphologically similar cancers. It is also valuable in identifying metastatic or poorly differentiated tumors with germ cell origins. Beyond diagnostics, SALL4 overexpression correlates with aggressive clinical behavior, therapy resistance, and poor prognosis in some cancers, implicating its role in oncogenesis through pathways like Wnt/β-catenin and PI3K/Akt.
Research further explores SALL4's therapeutic potential, as its inhibition in preclinical models reduces tumor growth. However, its utility requires context-dependent interpretation due to variable expression across tumor types and stages. Overall, SALL4 antibody serves as both a diagnostic cornerstone and a research tool for understanding cancer biology and stem cell mechanisms.
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