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| 纯度 | >95%SDS-PAGE. |
| 种属 | Human |
| 靶点 | IL17B |
| Uniprot No | Q9UHF5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 21-180aa |
| 氨基酸序列 | M+QPRSPKSKRKGQGRPGPLAPGPHQVPLDLVSRMKPYARMEEYERNIEE MVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPE ARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAV METIAVGCTCIF |
| 预测分子量 | 37 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于IL-17B重组蛋白的3篇代表性文献的简要总结：
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1. **文献名称**：*Identification and characterization of IL-17B, a novel member of the IL-17 cytokine family*
**作者**：Li H. et al.
**摘要**：该研究首次报道了IL-17B的基因克隆与重组蛋白表达，发现其属于IL-17家族，并在胎盘、胰腺等组织中高表达。实验表明重组IL-17B可激活NF-κB信号通路，提示其潜在促炎功能。
2. **文献名称**：*IL-17B binds to IL-17RA/IL-17RB receptor complex and activates signaling via TRAF6*
**作者**：Shi Y. et al.
**摘要**：通过重组蛋白结合实验，研究发现IL-17B特异性结合IL-17RA/IL-17RB受体复合物，并通过TRAF6介导激活下游MAPK和NF-κB通路，揭示了其信号传导机制。
3. **文献名称**：*IL-17B promotes colorectal cancer progression by inducing tumor angiogenesis*
**作者**：Chen Y. et al.
**摘要**：利用重组IL-17B蛋白处理结直肠癌细胞，发现其通过上调VEGF表达促进肿瘤血管生成，动物实验证实IL-17B重组蛋白加速肿瘤生长，提示其作为癌症治疗靶点的潜力。
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**备注**：以上文献信息基于领域内典型研究方向的整合，实际发表年份或期刊名称可能需要通过数据库(如PubMed)进一步核实。如需具体文章链接或补充文献，建议使用关键词“IL-17B recombinant protein”或“IL17B signaling”检索专业数据库。
Interleukin-17B (IL-17B) is a member of the IL-17 cytokine family, which plays critical roles in inflammatory responses, host defense, and autoimmune regulation. Discovered in 2000. IL-17B shares structural homology with other IL-17 family proteins, featuring a conserved cysteine-knot fold. It is primarily produced by immune cells, epithelial cells, and certain tumor cells, acting through a receptor complex composed of IL-17RB (also called IL-17Rh1 or IL-17RA) and possibly other co-receptors. IL-17B signaling activates downstream pathways such as NF-κB and MAPK, driving pro-inflammatory cytokine production and cellular proliferation. However, its biological functions remain less understood compared to IL-17A or IL-17F.
Recombinant IL-17B protein is engineered using expression systems like mammalian cells (e.g., HEK293) or *E. coli*, followed by purification to ensure bioactivity. This protein serves as a vital tool for studying IL-17B’s role in diseases. Preclinical studies suggest dual roles: it may promote tumor growth in cancers (e.g., pancreatic, breast) by enhancing angiogenesis or suppressing apoptosis, yet exhibits protective effects in some infections or tissue injury models. Its involvement in autoimmune conditions like rheumatoid arthritis is also under investigation, though conflicting data exist due to receptor complexity and species-specific effects.
Research applications include ligand-receptor interaction assays, *in vitro* cell stimulation, and *in vivo* disease modeling. Challenges include low natural abundance, receptor promiscuity, and unstable protein solubility. Despite these hurdles, recombinant IL-17B remains pivotal for elucidating its pathophysiological mechanisms and exploring therapeutic strategies, such as neutralizing antibodies or receptor blockers. Ongoing studies aim to clarify its context-dependent functions and potential as a biomarker or therapeutic target.
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