| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CALU |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是我模拟生成的关于CALU(Calumenin)抗体的参考文献示例，供参考使用(注：以下内容为虚构，实际文献请通过学术数据库查询)：
---
1. **文献名称**：*Calumenin as a Novel Biomarker in Colorectal Cancer: Diagnostic Potential of Anti-Calumenin Antibodies*
**作者**：Li, X.; Wang, H.; Zhang, Y.
**摘要**：本研究通过免疫组化分析，发现Calumenin在结直肠癌组织中高表达，并开发了特异性CALU抗体用于检测。结果显示，Calumenin表达水平与肿瘤转移呈正相关，提示其可能作为诊断标志物及治疗靶点。
2. **文献名称**：*Role of Calumenin in Vascular Smooth Muscle Cell Calcification: Insights from Antibody-Based Inhibition Studies*
**作者**：Johnson, R.K.; Müller, S.
**摘要**：利用CALU抗体阻断实验，证明Calumenin通过调节细胞内钙稳态参与血管平滑肌细胞钙化过程，为动脉粥样硬化的机制研究提供了新方向。
3. **文献名称**：*Anti-Calumenin Autoantibodies in Autoimmune Diseases: Correlation with Disease Activity*
**作者**：Chen, L.; Tanaka, M.; Rossi, F.
**摘要**：首次在系统性红斑狼疮(SLE)患者血清中检测到抗Calumenin自身抗体，其滴度与疾病活动度显著相关，提示CALU抗体可能参与自身免疫病理过程。
---
**建议**：实际研究中，请通过**PubMed**或**Google Scholar**以关键词“Calumenin antibody”、“Calumenin biomarker”等检索最新文献，或查阅以下领域期刊：
- *Journal of Cellular Biochemistry*
- *Clinical and Experimental Immunology*
- *Cardiovascular Research*
CALU (Calumenin) antibodies target a protein belonging to the CREC family, which is involved in calcium-binding and regulation within the endoplasmic reticulum (ER). Calumenin, encoded by the *CALU* gene, plays roles in modulating calcium-dependent processes, protein folding, and quality control in the ER. It interacts with other ER-resident chaperones, such as calreticulin and protein disulfide isomerase, influencing secretory pathway functions.
CALU antibodies are widely used in research to study its expression, localization, and functional roles in physiological and pathological contexts. Dysregulation of calumenin has been linked to cardiovascular diseases, cancer, and neurodegenerative disorders. For instance, altered calumenin levels are observed in atrial fibrillation, where calcium signaling is disrupted, and in certain cancers, where it may affect drug resistance or metastasis.
These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into ER stress, calcium homeostasis, and cellular responses to oxidative damage. Recent studies also explore calumenin's potential as a biomarker or therapeutic target, emphasizing its regulatory interplay with other calcium-handling proteins. Research using CALU antibodies continues to uncover its multifaceted roles in cellular physiology and disease mechanisms.
×
