| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | CKLiK; CaM-K1; CaMKID |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CAMK1D |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 **CAMK1D抗体** 的示例参考文献(注：以下内容为模拟生成，实际文献需通过学术数据库查询)：
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1. **文献名称**: *"CAMK1D regulates cell cycle progression in breast cancer via phosphorylation of p27Kip1"*
**作者**: Smith A, et al.
**摘要**: 本研究利用CAMK1D特异性抗体，通过免疫沉淀和Western blot技术，揭示了CAMK1D通过磷酸化p27Kip1调控乳腺癌细胞周期进程的机制，表明其高表达与患者预后不良相关。
2. **文献名称**: *"Neuronal CAMK1D signaling modulates synaptic plasticity in hippocampal neurons"*
**作者**: Yamaguchi T, et al.
**摘要**: 通过免疫组织化学和CAMK1D抗体的靶向抑制实验，发现CAMK1D在小鼠海马神经元突触可塑性中起关键作用，可能参与学习记忆相关的信号通路。
3. **文献名称**: *"Development and validation of a high-specificity CAMK1D monoclonal antibody for diagnostic applications"*
**作者**: Lee H, et al.
**摘要**: 研究报道了一种新型CAMK1D单克隆抗体的开发，经ELISA、免疫荧光和流式细胞术验证，证实其在多种组织样本中的高特异性和灵敏度，适用于癌症早期诊断。
4. **文献名称**: *"CAMK1D expression in metabolic syndrome: Insights from adipose tissue profiling"*
**作者**: Zhang R, et al.
**摘要**: 使用CAMK1D抗体分析肥胖患者脂肪组织样本，发现CAMK1D表达与胰岛素抵抗相关，提示其可能作为代谢综合征的潜在治疗靶点。
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**建议**：实际文献可通过 **PubMed**、**Google Scholar** 或 **Web of Science** 搜索关键词 *CAMK1D antibody*、*CAMK1D function* 等获取。
The CAMK1D antibody is a crucial tool for studying the calcium/calmodulin-dependent protein kinase 1 delta (CAMK1D), a serine/threonine kinase belonging to the Ca²⁺/calmodulin-dependent protein kinase (CAMK) family. CAMK1D is encoded by the CAMK1D gene and plays a role in calcium-mediated signaling pathways, regulating cellular processes such as gene transcription, cell cycle progression, and metabolism. It is activated by calcium/calmodulin binding and further phosphorylated by upstream kinases like CAMKK, enabling its full enzymatic activity. CAMK1D is expressed in various tissues, including the brain, pancreas, and immune cells, and has been implicated in diseases such as cancer, diabetes, and neurological disorders.
The CAMK1D antibody is specifically designed to detect endogenous CAMK1D protein levels in applications like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use it to investigate CAMK1D's expression patterns, post-translational modifications (e.g., phosphorylation at Thr180), and interactions within signaling cascades. Validated antibodies typically target epitopes within the kinase domain or regulatory regions, ensuring specificity by distinguishing CAMK1D from closely related isoforms (e.g., CAMK1. CAMK1G). Its development supports mechanistic studies of CAMK1D's role in cellular responses to calcium fluctuations, metabolic regulation, and pathological conditions, making it essential for both basic research and therapeutic target validation.
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