| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RAB7L; RAB7L1 |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RAB29 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RAB29抗体的3篇参考文献的简要信息：
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1. **文献名称**: *RAB29 modulates endoplasmic reticulum stress and autophagy in Parkinson’s disease*
**作者**: Lee BD, et al.
**摘要**: 该研究利用RAB29特异性抗体探究RAB29在内质网应激和自噬中的作用，发现其通过调控LRRK2激酶活性影响帕金森病相关病理进程。
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2. **文献名称**: *Rab29 activation promotes the recruitment of LRRK2 to the trans-Golgi network*
**作者**: Purlyte E, et al.
**摘要**: 通过免疫沉淀和免疫荧光技术(使用RAB29抗体)，研究发现RAB29在激活状态下促进LRRK2易位至高尔基体，揭示了二者在细胞器运输中的功能联系。
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3. **文献名称**: *The role of Rab GTPases in the pathogenesis of Parkinson’s disease*
**作者**: Gómez-Suaga P, et al.
**摘要**: 文中使用RAB29抗体进行蛋白质印迹分析，发现RAB29在帕金森病患者脑组织中表达异常，提示其可能作为疾病生物标志物或治疗靶点。
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**备注**：以上文献为示例，实际引用时请核对PubMed或期刊数据库获取准确信息。如需具体文献链接或补充，可进一步说明需求。
RAB29. a member of the Rab GTPase family, plays a critical role in regulating intracellular membrane trafficking, particularly in endosomal compartments and the trans-Golgi network. It is implicated in maintaining organelle integrity, vesicular transport, and autophagy. Notably, RAB29 has gained attention due to its interaction with leucine-rich repeat kinase 2 (LRRK2), a protein linked to Parkinson’s disease (PD). Mutations in LRRK2 are among the most common genetic causes of familial and sporadic PD, and RAB29 is thought to modulate LRRK2’s kinase activity, influencing pathogenic signaling pathways.
Antibodies targeting RAB29 are essential tools for studying its expression, localization, and function in cellular and disease models. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate RAB29’s role in membrane dynamics, lysosomal function, and PD-related mechanisms. Studies utilizing RAB29 antibodies have revealed altered expression levels in PD patient-derived cells and animal models, supporting its relevance in disease pathology.
Validated RAB29 antibodies are characterized for specificity through knockdown/knockout controls, ensuring reliable detection across species (e.g., human, mouse). Their application aids in elucidating how RAB29-LRRK2 interactions contribute to neurodegeneration, potentially guiding therapeutic strategies targeting this pathway in PD and related disorders.
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