| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TASSC; HSPC299; NIPSNAP4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NIPSNAP3A抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*NIPSNAP3A modulates mitochondrial metabolism in prostate cancer cells*
**作者**：Smith J, et al.
**摘要**：该研究通过NIPSNAP3A抗体检测发现，其在前列腺癌细胞线粒体代谢中起调控作用，抑制NIPSNAP3A会降低细胞呼吸并抑制肿瘤生长，提示其作为潜在治疗靶点。
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2. **文献名称**：*NIPSNAP3A as a diagnostic biomarker in colorectal cancer: Expression profiling and clinical validation*
**作者**：Lee S, Kim D.
**摘要**：利用免疫组化(NIPSNAP3A抗体)分析结直肠癌组织，发现NIPSNAP3A在癌变组织中高表达，且与患者预后不良相关，支持其作为诊断标志物的潜力。
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3. **文献名称**：*Functional interaction between NIPSNAP3A and mitophagy pathways in Parkinson’s disease models*
**作者**：Chen L, et al.
**摘要**：通过Western blot(使用NIPSNAP3A抗体)和基因敲除实验，发现NIPSNAP3A参与线粒体自噬调控，其异常表达与帕金森病模型中神经元退化相关。
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(注：以上文献信息为示例性概括，实际文献需通过PubMed或专业数据库检索确认。)
The NIPSNAP3A antibody is a tool used to detect the NIPSNAP3A protein, a member of the NipSnap (4-nitrophenylphosphatase domain and non-neuronal SNAP25-like) family. NIPSNAP3A, encoded by the *NIPSNAP3A* gene in humans, is a mitochondrial protein implicated in diverse cellular processes, including mitophagy, energy metabolism, and intracellular trafficking. Structurally, it contains a conserved NIPSNAP domain critical for protein-protein interactions. Studies suggest its role in mitochondrial quality control by recruiting autophagy receptors like OPTN and TAX1BP1 during stress, facilitating damaged mitochondrial clearance. Dysregulation of NIPSNAP3A has been linked to pathologies such as cancer, neurodegenerative disorders, and metabolic syndromes, though its precise mechanisms remain under investigation.
Antibodies targeting NIPSNAP3A are widely utilized in research to study its expression, localization, and function. They are validated for techniques like Western blotting, immunofluorescence, and immunohistochemistry, often in models of mitochondrial dysfunction or disease. Specificity is confirmed using knockout controls, ensuring recognition of the ~20 kDa protein. Recent studies highlight its potential as a biomarker in cancer, where altered expression correlates with tumor progression. Additionally, NIPSNAP3A antibodies aid in exploring its interaction networks, shedding light on mitochondrial dynamics and disease pathways. Continued research aims to clarify its therapeutic relevance in mitochondrial disorders and age-related conditions.
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