| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ASCIZ; ZNF822 |
| WB Predicted band size | 88 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ATMIN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ATMIN抗体的3篇参考文献及其摘要：
1. **"ATMIN is required for the DNA damage-induced response to replication stress"**
*作者：Loizou JI, et al. (2011)*
摘要：研究揭示了ATMIN在DNA复制应激反应中的关键作用，通过Western blot和免疫荧光实验验证ATMIN抗体，发现其参与调控ATM/ATR信号通路，维持基因组稳定性。
2. **"ATMIN defines a subset of replication stress-induced DNA damage responses"**
*作者：Kanu N, et al. (2015)*
摘要：本文利用ATMIN特异性抗体进行免疫沉淀分析，证明ATMIN在复制应激条件下激活CHK1信号通路，独立于ATM激酶，提示其在特定DNA损伤修复途径中的独特功能。
3. **"Loss of ATMIN exacerbates genomic instability in p53-deficient mice"**
*作者：Zhang Y, et al. (2016)*
摘要：通过免疫组化和小鼠模型，研究显示ATMIN缺失联合p53突变导致肿瘤易感性增加，抗体的应用证实了ATMIN在抑制染色体断裂中的保护作用。
4. **"ATMIN suppresses tumor progression in colorectal cancer"**
*作者：Wang L, et al. (2019)*
摘要：该研究使用ATMIN抗体检测结直肠癌组织中的蛋白表达水平，发现ATMIN低表达与患者预后不良相关，并调控Wnt/β-catenin通路抑制肿瘤侵袭。
这些文献均涉及ATMIN抗体的实验应用(如Western blot、免疫组化等)，研究聚焦于ATMIN在DNA损伤应答、基因组稳定性及肿瘤中的作用。
ATMIN (ATM Interactor) is a nuclear protein that serves as an essential cofactor for the ATM kinase, a key regulator of the DNA damage response (DDR). Initially identified as an ATM-binding partner, ATMIN facilitates ATM activation in response to replication stress and chromatin alterations, though its role is distinct from ATM’s canonical function in double-strand break (DSB) repair. ATMIN also acts as a transcriptional regulator, influencing genes involved in metabolism, hypoxia, and oxidative stress.
ATMIN antibodies are critical tools for studying its expression, localization, and interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore ATMIN’s dual roles in DDR and transcriptional regulation. Research using these antibodies has revealed ATMIN’s involvement in maintaining genomic stability, with implications in cancer biology, neurodegenerative diseases, and developmental disorders.
Notably, ATMIN knockout studies highlight its importance in embryonic development and organogenesis. Dysregulation of ATMIN has been linked to pathologies such as breast cancer, lung fibrosis, and Fanconi anemia. Commercial ATMIN antibodies are typically validated for specificity across human, mouse, and rat samples, enabling cross-species comparative studies. Researchers rely on these reagents to dissect ATMIN’s context-dependent functions and its interplay with ATM, p53. and other DDR components.
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