| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PSF2; Pfs2; HSPC037 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human GINS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GINS2抗体的示例参考文献(注：以下内容为模拟示例，非真实存在的文献，仅供格式参考)：
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1. **"GINS2 Antibody Validation in Hematopoietic Malignancies: A Tool for Prognostic Assessment"**
*Authors: Zhang Y, Chen L, Wang X*
**摘要**：本研究验证了GINS2抗体在白血病细胞系中的特异性，通过Western blot和免疫组化证实GINS2蛋白在急性髓系白血病(AML)中高表达，并与患者生存率负相关。抗体应用于临床样本分析，提示其作为潜在预后标志物。
2. **"Functional Characterization of GINS2 in Lung Cancer Using Monoclonal Antibodies"**
*Authors: Tanaka K, Suzuki R, Kim H*
**摘要**：开发了一种高特异性GINS2单克隆抗体，用于研究非小细胞肺癌(NSCLC)中GINS2的功能。通过免疫荧光和流式细胞术，发现GINS2沉默导致细胞周期停滞，抗体为靶向治疗研究提供了工具。
3. **"GINS2 Complex Localization in DNA Replication Studied via Custom Polyclonal Antibodies"**
*Authors: Müller S, García-Sánchez F, Lee J*
**摘要**：报道了一种新型多克隆GINS2抗体的制备与应用，结合免疫沉淀和质谱分析，揭示了GINS2在DNA复制起始阶段的动态定位，为研究复制应激机制提供了方法学支持。
4. **"GINS2 as a Biomarker in Breast Cancer: Immunohistochemical Analysis with a Novel Antibody"**
*Authors: Patel R, O'Connor M, Gupta S*
**摘要**：使用新开发的GINS2抗体对乳腺癌组织进行染色，发现其表达与肿瘤分级和转移相关。抗体特异性经siRNA敲低实验验证，支持其在病理诊断中的应用潜力。
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**建议**：如需真实文献，可访问PubMed或Google Scholar，搜索关键词如“GINS2 antibody validation”“GINS2 immunohistochemistry”或“GINS2 cancer”，并筛选涉及抗体开发、验证或应用的论文。
The GINS2 antibody targets a key subunit of the GINS complex, a critical component of the eukaryotic DNA replication machinery. The GINS complex (composed of SLD5. PSF1. PSF2. and GINS2) is essential for the initiation and elongation phases of DNA replication. It interacts with the minichromosome maintenance (MCM) helicase and CDC45 to form the CMG (CDC45-MCM-GINS) helicase complex, which unwinds DNA during replication. GINS2. also known as PSF2 or Pfs2. plays a structural and functional role in stabilizing the complex and ensuring proper replication fork progression.
Studies highlight GINS2's involvement in cell cycle regulation, particularly during the S and G2/M phases. Dysregulation of GINS2 expression has been linked to genomic instability, impaired replication, and diseases such as cancer, where its overexpression is observed in various malignancies. The GINS2 antibody is widely used in research to investigate DNA replication mechanisms, cell cycle dynamics, and cancer biology. It enables detection of GINS2 expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in the study of its localization, interactions, and pathological roles. As a tool, this antibody contributes to understanding replication-related disorders and potential therapeutic targets.
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