| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | JDP1; HPANBH4 |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human DNAJC12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DNAJC12抗体的3篇参考文献示例(文献信息为模拟生成，仅供参考)：
1. **《DNAJC12 mutations as a novel cause of autosomal recessive hyperphenylalaninemia》**
- **作者**: Anikster Y, et al.
- **摘要**: 该研究首次报道DNAJC12基因突变导致苯丙酮尿症样症状，并通过抗体检测发现患者细胞中DNAJC12蛋白表达显著降低，提示其作为分子伴侣在苯丙氨酸羟化酶调控中的作用。
2. **《DNAJC12 interacts with neurotoxic proteins in Parkinson's disease models》**
- **作者**: Smith J, Li R.
- **摘要**: 利用DNAJC12特异性抗体进行免疫共沉淀实验，证实其在帕金森病模型中与α-突触核蛋白相互作用，可能通过调节错误折叠蛋白的清除减缓神经退行性病变。
3. **《Development of a high-specificity monoclonal antibody for DNAJC12 detection in human tissues》**
- **作者**: Chen L, et al.
- **摘要**: 研究团队开发了一种新型单克隆抗体，经Western blot和免疫组化验证其对人类脑组织及肝脏中DNAJC12蛋白的高特异性和敏感性，为相关疾病诊断提供工具。
注：以上文献为示例，实际引用时建议通过PubMed或Google Scholar以“DNAJC12 antibody”为关键词检索最新研究。
**Background of DNAJC12 Antibody**
DNAJC12. a member of the HSP40/DNAJ chaperone family, functions as a co-chaperone for HSP70 proteins, aiding in cellular protein folding, stability, and degradation. It plays critical roles in neurotransmitter synthesis by regulating enzymes like tyrosine hydroxylase and tryptophan hydroxylase, which are essential for dopamine and serotonin production. Dysregulation of DNAJC12 is linked to neurological disorders, including early-onset parkinsonism, dystonia, and neurodevelopmental deficits.
DNAJC12 antibodies are valuable tools in studying its expression, localization, and interactions in cellular and disease contexts. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, helping to elucidate DNAJC12's role in protein quality control, stress responses, and neural homeostasis. Recent research also explores its potential involvement in cancer, where chaperone systems are often hijacked to support tumor progression.
By targeting DNAJC12. these antibodies contribute to understanding molecular mechanisms underlying neurodegenerative diseases and cancer, offering insights for therapeutic strategies. Their specificity ensures accurate assessment of DNAJC12 levels in pathological tissues, aiding biomarker discovery and mechanistic studies.
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