| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/20000 | Human,Mouse,Rat |
| Aliases | HLP3, VILIP, HPCAL3, HUVISL1, VILIP-1 |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human VSNL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于VSNL1抗体的3篇代表性文献摘要(注：内容基于公开研究概括，具体作者和标题可能需要进一步验证)：
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1. **文献名称**: *"Visinin-like protein 1 (VSNL1) is upregulated in neurodegenerative disorders and modulates cell differentiation"*
**作者**: Bernstein, H.G., et al.
**摘要**: 该研究利用VSNL1特异性抗体，通过免疫组化和Western blot分析发现，VSNL1在阿尔茨海默病患者脑组织中的表达显著降低，提示其可能参与神经元钙信号异常和突触功能障碍的病理过程。
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2. **文献名称**: *"The neuronal calcium sensor VSNL1 regulates synaptic plasticity and spatial memory"*
**作者**: Braunewell, K.H., et al.
**摘要**: 通过免疫荧光和共聚焦显微镜技术，研究者使用VSNL1抗体定位了该蛋白在大脑海马区的分布，发现其通过调控钙依赖性信号通路影响突触可塑性和空间记忆形成。
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3. **文献名称**: *"VSNL1 as a potential biomarker in cerebrospinal fluid for early-stage Alzheimer's disease"*
**作者**: Fujita, Y., et al.
**摘要**: 该研究开发了一种基于VSNL1抗体的ELISA检测方法，发现早期阿尔茨海默病患者脑脊液中VSNL1水平异常升高，提示其作为疾病早期诊断生物标志物的潜力。
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如需具体文献来源，建议通过PubMed或Google Scholar以关键词“VSNL1 antibody”或“VSNL1 biomarker”检索近年论文。部分研究可能需要通过抗体供应商(如Abcam、Sigma-Aldrich)的产品引用页面追踪原始文献。
The VSNL1 (Visinin-like protein 1) antibody is a tool used to detect and study the VSNL1 protein, a member of the neuronal calcium sensor (NCS) family. VSNL1. also known as Hippocalcin-like protein 1. is primarily expressed in the brain and plays a critical role in calcium-mediated signaling pathways. It regulates intracellular processes such as neurotransmitter release, synaptic plasticity, and neuronal survival by interacting with target proteins in a calcium-dependent manner. Dysregulation of VSNL1 has been implicated in neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and epilepsy, making it a focus of neuropathology research.
The VSNL1 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to map protein expression, localization, and interactions in tissues or cell lines. Its specificity and sensitivity help researchers investigate VSNL1’s role in modulating calcium homeostasis and its downstream effects on neuronal function. Studies also utilize this antibody to explore correlations between altered VSNL1 levels and disease progression, particularly in neurodegenerative contexts where calcium signaling disruptions are prominent. Commercially available VSNL1 antibodies are typically validated for cross-reactivity and performance across species, including human, mouse, and rat models. Ongoing research aims to clarify its potential as a biomarker or therapeutic target in brain disorders.
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