| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/240000 | Human,Mouse,Rat |
| Aliases | BNPI; VGLUT1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SLC17A7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC17A7抗体的3篇参考文献示例(内容为虚构，仅供格式参考)：
1. **文献名称**: *"VGLUT1/SLC17A7 Antibody Specificity in Glutamatergic Neuron Mapping*"
**作者**: Takamori, S., et al.
**摘要**: 本研究验证了SLC17A7抗体在识别中枢神经系统谷氨酸能神经元中的特异性，通过免疫组化和基因敲除实验证实其标记VGLUT1蛋白的可靠性，为突触传递研究提供工具。
2. **文献名称**: *"SLC17A7 as a Biomarker in Neurodegenerative Diseases: Antibody-based Detection*"
**作者**: Barker-Haliski, M., & Smith, J.
**摘要**: 探讨SLC17A7抗体在阿尔茨海默病患者脑组织中的表达变化，发现其与谷氨酸能突触丢失相关，提示其作为疾病进展标志物的潜力。
3. **文献名称**: *"Comparative Analysis of SLC17A7 Antibodies for Western Blot and Immunofluorescence*"
**作者**: Miyazaki, T., et al.
**摘要**: 系统比较了四种商业SLC17A7抗体的灵敏度和交叉反应性，推荐特定抗体用于不同实验场景(如脑切片染色或蛋白定量)。
*注：以上文献信息为模拟生成，实际引用需查询PubMed等数据库获取真实文献。*
The SLC17A7 antibody targets the solute carrier family 17 member 7 (SLC17A7) protein, also known as vesicular glutamate transporter 1 (VGLUT1). This transporter is critical for packaging the neurotransmitter glutamate into synaptic vesicles, enabling glutamatergic signaling in the central nervous system. VGLUT1 is predominantly expressed in excitatory neurons, particularly in the cerebral cortex, hippocampus, and cerebellum, where it regulates synaptic plasticity, learning, and memory.
SLC17A7 antibodies are widely used in neuroscience research to identify and map glutamatergic neurons, study synaptic connectivity, and investigate disorders linked to glutamate dysregulation, such as Alzheimer's disease, epilepsy, and schizophrenia. These antibodies are validated for techniques like immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF). Specificity is crucial, as cross-reactivity with other VGLUT isoforms (e.g., VGLUT2 or VGLUT3) could lead to misinterpretation. High-quality SLC17A7 antibodies typically show distinct labeling patterns in brain regions rich in VGLUT1. such as layered cortical structures, aiding in the functional dissection of glutamatergic pathways. Their application has advanced understanding of excitatory neurotransmission and its role in both normal physiology and disease.
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