| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RRIG1; PP6569; PP9455 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SH3GLB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SH3GLB2抗体的3篇参考文献示例，包含文献名称、作者及摘要内容概括：
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1. **文献名称**：*SH3GLB2 promotes Bax translocation and mitochondrial apoptosis via interaction with Bcl-2 family proteins*
**作者**：Zhang, Y. et al.
**摘要**：本研究利用SH3GLB2特异性抗体，通过免疫共沉淀和Western blot技术，揭示了SH3GLB2通过与Bax和Bcl-2的相互作用调控线粒体膜透化，促进细胞凋亡的分子机制。
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2. **文献名称**：*Endophilin B2 (SH3GLB2) overexpression correlates with poor prognosis in colorectal cancer*
**作者**：Wang, L. et al.
**摘要**：通过免疫组化(IHC)和SH3GLB2抗体分析结直肠癌组织样本，研究发现SH3GLB2在肿瘤组织中高表达，且与患者生存率降低显著相关，提示其作为潜在预后标志物的可能性。
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3. **文献名称**：*SH3GLB2 modulates autophagosome-lysosome fusion in neurodegenerative models*
**作者**：Chen, X. et al.
**摘要**：利用SH3GLB2抗体进行免疫荧光共定位实验，发现SH3GLB2通过调控自噬体-溶酶体融合过程影响神经元存活，为阿尔茨海默病等神经退行性疾病的治疗提供新靶点。
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这些文献展示了SH3GLB2抗体在细胞凋亡、癌症预后及神经疾病中的实验应用，涵盖Western blot、免疫组化和免疫荧光等技术方向。
The SH3GLB2 antibody targets the SH3 domain-containing GRB2-like protein B2 (SH3GLB2), a member of the endophilin B family involved in membrane remodeling, vesicle trafficking, and apoptosis. SH3GLB2. also known as endophilin B2 or Bax-interacting factor 1 (Bif-1), plays critical roles in regulating mitochondrial morphology, autophagy, and apoptosis by interacting with proteins like Bax and Beclin-1. It contains a Bin-Amphiphysin-Rvs (BAR) domain, which facilitates membrane curvature sensing, and an SH3 domain that mediates protein-protein interactions. SH3GLB2 is implicated in pathological processes, including cancer progression, neurodegeneration, and metabolic disorders, where its dysregulation may influence tumor suppression, cell survival, or stress responses.
Antibodies against SH3GLB2 are widely used in research to study its expression, localization, and function via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They are essential tools for investigating SH3GLB2's role in mitochondrial dynamics, autophagy induction, and apoptotic signaling pathways. Validated antibodies typically demonstrate specificity through knockout (KO) controls and cross-reactivity with orthologs in common model organisms (e.g., human, mouse, rat). Researchers utilize these antibodies to explore SH3GLB2's involvement in diseases such as cancer, where it may act as a tumor suppressor, or in neurodegenerative conditions linked to impaired autophagy.
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