| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CREST; LP2261 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SS18L1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是几篇关于SS18L1抗体的模拟参考文献(注：以下内容为示例性模拟，实际文献需通过学术数据库验证)：
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1. **文献名称**：*SS18L1 as a Novel Biomarker in Synovial Sarcoma: Immunohistochemical Analysis*
**作者**：Smith A, et al.
**摘要**：本研究通过免疫组化技术验证了SS18L1抗体在滑膜肉瘤组织中的特异性表达，发现SS18L1与SS18-SSX融合蛋白存在共定位，提示其可能参与肿瘤发生机制。
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2. **文献名称**：*Characterization of SS18L1 Antibody for Chromatin Remodeling Studies*
**作者**：Chen L, et al.
**摘要**：文章报道了一种高特异性SS18L1抗体的开发，用于Western blot和ChIP实验，证实SS18L1在SWI/SNF染色质重塑复合体中的功能性作用及其与癌症转移的关联。
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3. **文献名称**：*SS18L1 Expression in Neural Development: Insights from Knockout Models*
**作者**：Wang Y, et al.
**摘要**：利用SS18L1抗体进行小鼠脑组织分析，发现SS18L1在神经干细胞分化中调控关键基因表达，缺失该蛋白导致神经发育异常。
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4. **文献名称**：*Comparative Study of SS18 and SS18L1 Antibodies in Diagnostic Pathology*
**作者**：Johnson R, et al.
**摘要**：比较了SS18和SS18L1抗体在多种肿瘤中的交叉反应性，提出SS18L1抗体可作为鉴别SS18相关肿瘤亚型的重要工具。
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**建议**：以上为模拟文献，实际研究中请通过PubMed、Google Scholar等平台检索真实文献(关键词：SS18L1 antibody, SS18L1 protein, cancer biomarkers)。
The SS18L1 (SS18 Like 1) antibody is a tool used to detect the SS18L1 protein, a homolog of SS18. a component of the SWI/SNF chromatin remodeling complex. SS18L1 shares structural similarities with SS18. including a conserved SNH domain, but lacks the SYT domain found in its counterpart. This protein is implicated in transcriptional regulation, chromatin organization, and cellular differentiation. Research has shown that SS18L1 interacts with transcription factors and other SWI/SNF subunits, influencing gene expression programs critical for development and tissue homeostasis.
The SS18L1 antibody is particularly valuable in studying its role in cancer and neurological disorders. While SS18 is frequently involved in synovial sarcoma due to SS18-SSX fusion genes, SS18L1 has been linked to neural development and diseases like spinocerebellar ataxia. Antibody applications include Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and interactions in experimental models.
Validated antibodies against SS18L1 help distinguish it from SS18. aiding research into functional divergence between these paralogs. Recent studies also explore SS18L1's potential as a biomarker or therapeutic target in conditions marked by chromatin dysregulation. Proper validation ensures specificity, minimizing cross-reactivity with SS18 or other family members, which is crucial for accurate interpretation in both basic and translational contexts.
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