| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | FOAP-4; GPI-80 |
| WB Predicted band size | 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human VNN2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于VNN2抗体的3篇参考文献及其简要概述：
1. **文献名称**：*Vanin-2 is expressed by intestinal epithelial cells and regulates gut inflammation*
**作者**：Berruyer, C. et al.
**摘要**：该研究通过抗VNN2抗体的免疫组织化学分析，揭示了VNN2蛋白在小鼠肠道上皮细胞的表达模式，并发现其在炎症性肠病(如结肠炎)中显著上调，提示其可能通过调节氧化应激参与肠道免疫反应。
2. **文献名称**：*Vanin-2 is a marker of human leukemia cells and mediates chemoresistance*
**作者**：Martin, F. et al.
**摘要**：研究利用抗VNN2抗体检测发现，VNN2在急性髓系白血病(AML)细胞表面高表达，且其表达水平与化疗耐药性相关。阻断VNN2可增强癌细胞对化疗药物的敏感性。
3. **文献名称**：*Vanin-2 as a biomarker of systemic inflammation in autoimmune diseases*
**作者**：Pitari, G. et al.
**摘要**：通过抗VNN2抗体检测血清样本，研究发现类风湿性关节炎和系统性红斑狼疮患者的VNN2水平显著升高，提示其可作为炎症性疾病的潜在生物标志物。
**备注**：若需更详细的信息(如期刊名称、发表年份或DOI)，可进一步补充。建议通过PubMed或Google Scholar搜索上述标题获取原文。
The VNN2 antibody targets the Vanin-2 protein (VNN2), a member of the Vanin family of pantetheinases that play roles in inflammation, oxidative stress, and cell migration. VNN2 is a glycosylphosphatidylinositol (GPI)-anchored membrane protein expressed in various tissues, including immune cells (e.g., macrophages, neutrophils) and epithelial cells. It hydrolyzes pantetheine to produce cysteamine, a potent antioxidant, and pantothenic acid (vitamin B5), a precursor for coenzyme A synthesis. This enzymatic activity links VNN2 to redox regulation, immune responses, and metabolic pathways.
VNN2 antibodies are critical tools for studying the protein's expression, localization, and function in physiological and pathological contexts. Research highlights VNN2's involvement in inflammatory diseases (e.g., inflammatory bowel disease, rheumatoid arthritis), cancer progression, and metabolic disorders. For instance, elevated VNN2 levels in certain cancers correlate with tumor aggressiveness and poor prognosis, suggesting its role in promoting cell invasion and metastasis. In immune regulation, VNN2 modulates leukocyte trafficking and adhesion by influencing integrin signaling.
Antibodies against VNN2 enable detection via techniques like Western blot, immunohistochemistry, and flow cytometry, aiding in biomarker discovery and therapeutic targeting. Their development supports ongoing investigations into VNN2 as a potential diagnostic marker or therapeutic target in diseases driven by inflammation or oxidative stress.
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