WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 咨询技术 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
WB Predicted band size | 100 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Synthetic peptide of human ZNF624 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZNF624抗体的模拟参考文献示例(注:因ZNF624研究较少,以下内容为假设性示例,实际文献需通过学术数据库核实):
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1. **文献名称**: *ZNF624 functions as a transcriptional repressor in hepatocellular carcinoma*
**作者**: Li X, et al.
**摘要**: 本研究利用ZNF624抗体通过免疫组化(IHC)和Western blot分析,发现ZNF624在肝癌组织中高表达,并通过调控下游靶基因促进肿瘤细胞增殖。抗体特异性经siRNA敲低验证。
2. **文献名称**: *Characterization of ZNF624 antibody for chromatin immunoprecipitation (ChIP) applications*
**作者**: Smith J, et al.
**摘要**: 文章报道了一种新型ZNF624多克隆抗体的开发,验证了其在ChIP-seq中的适用性,确认ZNF624结合基因组非编码区域,可能参与干细胞分化调控。
3. **文献名称**: *ZNF624 expression and its epigenetic regulation in Alzheimer's disease*
**作者**: Wang Y, et al.
**摘要**: 通过ZNF624抗体检测脑组织样本,发现阿尔茨海默病患者中ZNF624蛋白水平下降,且其表达受DNA甲基化调控,提示其与神经元保护通路相关。
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**注意**:以上文献为模拟内容,ZNF624抗体的实际研究可能有限,建议通过PubMed、Google Scholar或抗体厂商(如Abcam、CST)的技术资料获取真实数据。
The ZNF624 antibody is a research tool designed to detect and study the zinc finger protein 624 (ZNF624), a member of the zinc finger protein family characterized by conserved C2H2-type zinc finger domains. These proteins typically function as transcription factors, regulating gene expression by binding to DNA or interacting with other proteins. ZNF624 is thought to play roles in cellular processes such as differentiation, proliferation, and development, though its precise biological functions remain under investigation. It has been implicated in several studies exploring its potential involvement in cancer, neurological disorders, and other diseases linked to transcriptional dysregulation.
Commercially available ZNF624 antibodies are commonly produced in hosts like rabbits or mice, using immunogens derived from specific regions of the human ZNF624 protein. These antibodies enable applications including Western blotting, immunohistochemistry, immunofluorescence, and chromatin immunoprecipitation (ChIP) to analyze protein expression, localization, and DNA-binding activity. Validation data, such as knockout cell line controls or siRNA-mediated knockdowns, are critical to confirm antibody specificity. Researchers utilize ZNF624 antibodies to explore its regulatory networks, interactions with signaling pathways, and potential as a biomarker or therapeutic target. Ongoing studies aim to elucidate its role in health and disease, particularly in contexts where zinc finger proteins are known to influence epigenetic regulation or oncogenesis.
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