| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | ZUD; MUXA |
| WB Predicted band size | 58 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human UNC5CL |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UNC5CL抗体的模拟参考文献示例(请注意，部分文献信息为假设性概括，实际研究中需核实具体内容)：
1. **文献名称**: "UNC5CL as a Novel Regulator of Apoptosis in Hepatocellular Carcinoma"
**作者**: Zhang L, et al.
**摘要**: 本研究利用UNC5CL特异性抗体进行免疫组化分析，发现UNC5CL在肝癌组织中显著低表达，并通过激活caspase通路促进肿瘤细胞凋亡，提示其作为潜在治疗靶点。
2. **文献名称**: "Expression Profiling of UNC5CL in Immune Cells Using a Monoclonal Antibody Approach"
**作者**: Smith J, et al.
**摘要**: 通过开发高特异性UNC5CL单克隆抗体，研究揭示了该受体在T细胞和树突状细胞中的差异性表达，并探讨了其在免疫调控中的潜在作用。
3. **文献名称**: "UNC5CL Antibody Validation for Flow Cytometry and Western Blot Applications"
**作者**: Tanaka K, et al.
**摘要**: 文章系统验证了商业化UNC5CL抗体在流式细胞术及Western Blot中的适用性，确认其在多种细胞系中的特异性信号及交叉反应性数据。
4. **文献名称**: "Epigenetic Silencing of UNC5CL Promotes Breast Cancer Metastasis"
**作者**: Wang Y, et al.
**摘要**: 通过UNC5CL抗体检测乳腺癌患者样本，发现其表达缺失与肿瘤转移显著相关，机制研究表明DNA甲基化介导的UNC5CL抑制可增强细胞迁移能力。
**注意**：以上文献为模拟内容，实际研究中请通过PubMed、Web of Science等平台以“UNC5CL antibody”或“UNC5CL function”为关键词检索最新文献。若研究UNC5C(同家族成员)，可参考更多已发表数据。
The UNC5CL antibody is a tool used to detect UNC5CL (UNC-5 homolog C-like), a transmembrane protein belonging to the UNC-5 family of netrin receptors. These receptors are involved in regulating cell migration, survival, and apoptosis, primarily through interactions with netrins, a class of guidance molecules. UNC5CL shares structural homology with other UNC-5 family members (UNC5A-D), including immunoglobulin-like domains and a death domain, but exhibits distinct expression patterns and functional roles. It is implicated in both netrin-dependent and -independent signaling pathways, influencing processes like angiogenesis, neurodevelopment, and immune regulation.
Research suggests UNC5CL may act as a dependence receptor, promoting apoptosis in the absence of netrin ligands, a feature linked to tumor suppression. Its expression is often dysregulated in cancers, including colorectal and hepatocellular carcinomas, highlighting its potential role in oncogenesis. The UNC5CL antibody enables the study of its expression, localization, and interactions in various tissues and disease models. It is widely used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to explore UNC5CL's biological functions and therapeutic relevance. Validated antibodies are critical for distinguishing UNC5CL from homologous proteins, ensuring specificity in experimental outcomes. Ongoing studies aim to clarify its mechanistic roles in disease pathways and assess its viability as a diagnostic marker or therapeutic target.
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