| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | WARBM3, RAB18LI1 |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human RAB18 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于RAB18抗体的相关文献概览：
1. **文献名称**：*RAB18 Loss Causes Neuromotor Dysfunction and Cholesterol Metabolism Imbalance*
**作者**：Vazquez-Martinez et al.
**摘要**：研究利用RAB18抗体进行蛋白质印迹分析，发现RAB18缺失会导致细胞内胆固醇转运异常，并引发小鼠运动神经元功能障碍，提示其与遗传性神经系统疾病相关。
2. **文献名称**：*Role of RAB18 in Lipid Droplet Dynamics and Adipocyte Differentiation*
**作者**：Liu et al.
**摘要**：通过免疫荧光技术结合RAB18特异性抗体，揭示RAB18调控脂滴融合及脂肪细胞分化的分子机制，为代谢性疾病研究提供依据。
3. **文献名称**：*Antibody-based Profiling of RAB18 Expression in Human Cancers*
**作者**：Zhang et al.
**摘要**：利用商业化RAB18抗体对多种肿瘤组织进行免疫组化分析，发现RAB18在肝癌中高表达，可能与肿瘤细胞分泌通路异常激活相关。
注：以上文献信息为示例性质，实际引用需核对真实出版物数据。建议通过PubMed或Web of Science以“RAB18 antibody”为关键词检索最新研究。
**Background of RAB18 Antibody**
RAB18 is a small GTPase belonging to the RAS superfamily, involved in intracellular membrane trafficking, lipid droplet dynamics, and autophagy. It plays critical roles in regulating endoplasmic reticulum (ER)-Golgi transport, lipid metabolism, and cellular energy homeostasis. Dysregulation of RAB18 is linked to Warburg Micro syndrome, a rare autosomal recessive disorder characterized by neurodevelopmental defects, ocular abnormalities, and endocrine dysfunction.
RAB18 antibodies are essential tools for studying its expression, localization, and function. These antibodies are typically generated using recombinant RAB18 protein or synthetic peptides as immunogens, often in rabbits or mice. Validation includes Western blotting, immunofluorescence, and immunohistochemistry to confirm specificity, often using knockout cell lines or tissues as controls.
RAB18 antibodies enable researchers to investigate its interaction with effectors like RAB3GAP1/2 complexes and its role in diseases such as neurodegenerative disorders, metabolic syndromes, and cancer. Commercial antibodies vary in clonality (monoclonal/polyclonal), host species, and applications, with some targeting specific post-translational modifications (e.g., prenylation). Recent studies also explore RAB18 as a potential therapeutic target, highlighting the antibody's utility in both basic research and translational medicine.
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