Rabbit Polyclonal RHOB Antibody

RHOB, a member of the Rho GTPase family, plays critical roles in regulating cytoskeletal dynamics, cell migration, proliferation, and stress response. Unlike other Rho proteins, RHOB exhibits unique characteristics, such as rapid induction by cellular stress (e.g., DNA damage, hypoxia) and distinct subcellular localization, often associated with endosomes or nuclear membranes. Its expression is tightly regulated at transcriptional and post-translational levels, including lipid modifications for membrane anchoring. RHAB抗體 (RHOB antibodies) are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate RHOB's role in cancer, where it displays dual roles—acting as a tumor suppressor in some cancers (e.g., lung, breast) or promoting invasiveness in others (e.g., glioblastoma). Research also highlights RHOB's involvement in vesicle trafficking, apoptosis, and modulating signaling pathways like MAPK and PI3K/AKT. Dysregulation of RHOB is linked to drug resistance, metastasis, and poor prognosis, making it a potential therapeutic target. Validated RHOB antibodies help unravel its context-dependent mechanisms, aiding the development of targeted therapies for cancers and other diseases involving cytoskeletal or signaling aberrations.