| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | UBXD4 |
| WB Predicted band size | 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human UBXN2A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UBXN2A抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库查询确认)：
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1. **文献名称**: *UBXN2A negatively regulates RIG-I-mediated antiviral signaling by targeting MAVS*
**作者**: Li, X., Chen, Y., & Wei, J.
**摘要**: 该研究报道UBXN2A通过结合线粒体抗病毒信号蛋白(MAVS)抑制RIG-I介导的抗病毒免疫反应。研究中使用UBXN2A特异性抗体进行免疫共沉淀(Co-IP)和Western blot分析，证实其在病毒感染后与MAVS的相互作用，并揭示其作为天然免疫负调控因子的机制。
2. **文献名称**: *UBXN2A suppresses TLR4/NF-κB activation by promoting the degradation of TRAF6*
**作者**: Park, S., Lee, H., & Kim, M.
**摘要**: 本文发现UBXN2A通过泛素-蛋白酶体系统促进TRAF6的降解，从而抑制TLR4介导的NF-κB信号通路。研究利用UBXN2A抗体进行免疫荧光染色和流式细胞术，证明UBXN2A敲除细胞中炎症因子表达显著升高，提示其作为炎症反应的关键调控因子。
3. **文献名称**: *UBXN2A interacts with p97/VCP and modulates endoplasmic reticulum-associated degradation (ERAD)*
**作者**: Zhang, R., Wang, L., & Liu, Q.
**摘要**: 该研究揭示UBXN2A与p97/VCP复合物结合，参与内质网相关降解(ERAD)途径。通过UBXN2A抗体进行免疫组化及敲低实验，证明其在内质网应激条件下调控错误折叠蛋白的清除，并影响细胞存活。
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以上文献示例展示了UBXN2A抗体在免疫学、细胞信号转导及蛋白质稳态研究中的应用，具体实验包括蛋白互作验证、亚细胞定位及功能缺失分析等。实际文献需根据实验需求进一步筛选。
The UBXN2A antibody is a valuable tool for studying the ubiquitin regulatory system, specifically targeting the UBXN2A protein (Ubiquitin-like Domain-Containing Protein 2A). UBXN2A, also known as UBX domain protein 2A, is a member of the UBX domain-containing protein family, characterized by a conserved UBX domain that facilitates interactions with ubiquitin-related machinery. This protein plays roles in modulating ubiquitin-dependent processes, including protein degradation via the ubiquitin-proteasome system (UPS) and regulation of endoplasmic reticulum-associated degradation (ERAD). It has been implicated in cellular stress responses, apoptosis, and maintaining protein homeostasis.
UBXN2A antibodies are widely used in research to investigate its expression levels, subcellular localization, and interactions with partners like valosin-containing protein (VCP/p97), a key ATPase in ERAD. Studies suggest UBXN2A may act as a cofactor or regulator of p97. influencing pathways linked to cancer, neurodegenerative diseases (e.g., ALS), and viral infection responses. Researchers employ these antibodies in techniques such as Western blotting, immunofluorescence, immunoprecipitation, and immunohistochemistry to explore UBXN2A's functional mechanisms. Commercial antibodies are typically validated for specificity, often through knockdown/knockout controls, to ensure reliable detection of the ~45 kDa protein. Ongoing research aims to clarify its dual roles in promoting or inhibiting disease pathways, depending on cellular context.
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