| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ARFL2; MRCS1 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ARL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与ARL2抗体相关的文献摘要示例(基于公开研究领域归纳，非真实文献，仅供格式参考)：
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1. **文献名称**: "Characterization of ARL2 interactions with BART reveals roles in ciliary trafficking"
**作者**: Bhamidipati, A., et al.
**摘要**: 研究利用ARL2特异性抗体，通过免疫共沉淀和质谱分析，鉴定出ARL2与BART蛋白的相互作用，并证明该复合物在纤毛相关蛋白运输中的调控作用，为纤毛疾病机制提供新见解。
2. **文献名称**: "Structural insights into ARL2-GTPase activation and microtubule binding"
**作者**: Sharer, J.D., et al.
**摘要**: 通过ARL2抗体的免疫荧光染色，结合X射线晶体学，揭示了ARL2的GTP结合结构域构象变化及其与微管蛋白的相互作用，阐明了其在微管动力学调控中的分子机制。
3. **文献名称**: "ARL2 overexpression correlates with poor prognosis in ovarian cancer"
**作者**: Francis, J.W., et al.
**摘要**: 采用ARL2抗体对卵巢癌组织进行免疫组化分析，发现ARL2在癌细胞中高表达且与化疗耐药性相关，提示其可能作为潜在治疗靶点。
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如需具体文献，建议通过PubMed或Google Scholar以“ARL2 antibody”或“ARL2 function”为关键词检索近年研究。真实文献可能聚焦于ARL2的细胞定位、疾病关联或结合蛋白研究。
The ARL2 (ADP-ribosylation factor-like 2) antibody is a tool used to study the ARL2 protein, a member of the ADP-ribosylation factor (ARF) family within the Ras superfamily of small GTPases. ARL2 plays critical roles in regulating microtubule dynamics, mitochondrial function, and intracellular trafficking. Unlike canonical ARF proteins, ARL2 does not activate phospholipase D but instead interacts with specific effectors like BART (binding partner of ARL2) to modulate tubulin folding via its association with tubulin-specific chaperone TBCD. It also influences mitochondrial ATP/ADP exchange by binding to the mitochondrial adenine nucleotide transporter ANT1. Dysregulation of ARL2 has been linked to cancers, neurological disorders, and ciliopathies due to its role in cellular homeostasis.
ARL2 antibodies are essential for detecting endogenous ARL2 expression, localization, and post-translational modifications in research applications such as Western blotting, immunofluorescence, and immunoprecipitation. These antibodies are typically raised in hosts like rabbits or mice, with monoclonal and polyclonal variants available. Validation often includes knockout controls or siRNA knockdown to confirm specificity. Researchers rely on ARL2 antibodies to explore its regulatory mechanisms in cell cycle progression, apoptosis, and organelle integrity, making it a valuable reagent in studies of cellular biology and disease pathogenesis.
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