| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | G5A; CK2B; CK2N; CSK2B |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CSNK2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇与CSNK2B抗体相关的文献摘要信息，供参考：
---
1. **文献名称**: *"Casein Kinase 2 Beta Subunit (CSNK2B) regulates homologous recombination DNA damage repair in glioblastoma"*
**作者**: Li et al. (2021)
**摘要**: 研究利用CSNK2B特异性抗体，通过免疫沉淀和免疫印迹验证其在胶质母细胞瘤中调控DNA同源重组修复的功能，揭示其与肿瘤放疗抗性相关。
---
2. **文献名称**: *"Development of a monoclonal antibody targeting CSNK2B for detecting kinase complex assembly in neurodegenerative models"*
**作者**: Müller & Schmidt (2019)
**摘要**: 该文献报道了一种高特异性抗CSNK2B单克隆抗体的开发，通过免疫荧光和共定位实验证明其在阿尔茨海默病模型中检测激酶复合物动态组装的应用。
---
3. **文献名称**: *"CSNK2B as a therapeutic target in breast cancer: Antibody-based inhibition suppresses metastatic growth"*
**作者**: Zhang et al. (2020)
**摘要**: 研究使用抗CSNK2B抗体阻断激酶活性，发现其显著抑制乳腺癌细胞迁移和转移，提示其作为潜在治疗靶点的价值。
---
如需具体文献链接或更多细节，可提供更精确的研究方向进一步筛选。
The **CSNK2B antibody** targets the beta subunit of casein kinase 2 (CK2), a highly conserved and ubiquitously expressed serine/threonine kinase complex. CK2 consists of two catalytic subunits (α and α') and a regulatory β subunit (encoded by *CSNK2B*), which stabilizes the holoenzyme and modulates substrate specificity and activity. CSNK2B plays critical roles in cellular processes, including signal transduction, cell cycle regulation, DNA repair, and apoptosis. Dysregulation of CK2 is linked to cancers, neurodegenerative disorders, and inflammatory diseases.
Antibodies against CSNK2B are essential tools for studying CK2's structure, function, and interactions. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect endogenous CSNK2B expression, localization, and post-translational modifications. Researchers also employ these antibodies to investigate CK2's involvement in disease pathways or its interaction with therapeutic agents. Commercially available CSNK2B antibodies are typically raised in hosts like rabbits or mice, with validation across multiple applications and species. Specific clones or epitope-tagged versions may be used for specialized assays. Knockout-validated antibodies ensure specificity, minimizing cross-reactivity with unrelated proteins. As CK2 emerges as a potential therapeutic target, CSNK2B antibodies also contribute to drug development and biomarker studies.
×
