| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CP25; HOX3; HOX3C; HHO.C8 |
| WB Predicted band size | 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXC6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOXC6抗体的3篇参考文献示例，包含文献名称、作者及摘要概括：
1. **文献名称**：*HOXC6 promotes prostate cancer progression via extracellular matrix remodeling*
**作者**：Smith et al. (2018)
**摘要**：本研究利用HOXC6抗体进行免疫组化分析，发现HOXC6在前列腺癌组织中高表达，并与肿瘤侵袭性及细胞外基质重塑相关。实验表明，HOXC6通过调控MMP蛋白家族促进转移。
2. **文献名称**：*HOXC6 expression correlates with poor prognosis in triple-negative breast cancer*
**作者**：Lee et al. (2020)
**摘要**：通过HOXC6抗体检测乳腺癌组织样本，发现HOXC6在三阴性乳腺癌中显著高表达，且与患者生存率下降和化疗耐药性相关，提示其作为潜在治疗靶点。
3. **文献名称**：*Developmental regulation of HOXC6 in murine embryogenesis*
**作者**：Garcia et al. (2016)
**摘要**：使用HOXC6抗体分析小鼠胚胎发育，发现HOXC6在肢体形成和神经管发育中动态表达，揭示其在细胞分化和组织模式建立中的关键作用。
4. **文献名称**：*Validation of a novel HOXC6 monoclonal antibody for diagnostic applications*
**作者**：Chen et al. (2021)
**摘要**：研究验证了一种高特异性HOXC6单克隆抗体，通过Western blot和免疫荧光证实其在多种癌症组织中的检测灵敏度，为临床诊断提供可靠工具。
(注：上述文献信息为示例性质，实际引用时需核实真实文献。)
**Background of HOXC6 Antibody**
HOXC6 is a member of the HOX gene family, which encodes transcription factors critical for embryonic development, particularly in establishing body patterning and cellular differentiation. Located on chromosome 12q13.13. HOXC6 regulates morphogenesis by controlling gene expression in specific spatial and temporal contexts. It plays roles in limb development, neural tube formation, and organogenesis. In adult tissues, HOXC6 expression persists in certain organs, such as the prostate, uterus, and mammary glands, where it influences cellular proliferation and differentiation.
Antibodies targeting HOXC6 are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect HOXC6 protein levels in cells and tissues. Such antibodies aid in exploring HOXC6's involvement in developmental disorders and diseases, including cancer. For instance, aberrant HOXC6 expression is linked to tumor progression in prostate, breast, and ovarian cancers, where it may promote metastasis or therapy resistance.
HOXC6 antibodies also support research into stem cell biology, as HOXC6 regulates stem cell differentiation and tissue regeneration. Validation of these antibodies includes specificity checks using knockout controls and cross-reactivity assessments. Understanding HOXC6's role through antibody-based studies provides insights into developmental pathways and potential therapeutic targets for cancers or regenerative medicine.
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