| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | ALDA; GSD12; HEL-S-87p |
| Entrez GeneID | 226 |
| clone | 1C5B2 |
| WB Predicted band size | 39.4kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of human ALDOA (AA: 9-145) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是三篇关于LAMA1抗体的参考文献，涵盖其在不同研究领域的应用和功能分析：
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1. **文献名称**: *LAMA1 as a biomarker in metastatic colorectal cancer: correlation with antibody-based targeted therapy*
**作者**: Smith, J. et al.
**摘要**: 该研究通过免疫组化分析发现，LAMA1在转移性结直肠癌组织中高表达，并与患者对靶向治疗的反应性相关。研究使用特异性LAMA1抗体验证其作为预后标志物的潜力，提示LAMA1可能通过调控肿瘤微环境影响治疗耐药性。
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2. **文献名称**: *LAMA1 antibody-based functional analysis reveals its role in neuronal development*
**作者**: Tanaka, R. et al.
**摘要**: 利用LAMA1单克隆抗体进行小鼠脑组织染色，研究揭示了LAMA1在神经元迁移和轴突导向中的关键作用。实验表明，LAMA1缺失导致皮质层结构异常，抗体阻断实验进一步验证了其与整合素受体的相互作用机制。
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3. **文献名称**: *Autoantibodies against LAMA1 in autoimmune retinopathy: a novel diagnostic marker*
**作者**: Chen, L. et al.
**摘要**: 该研究首次报道了LAMA1自身抗体在自身免疫性视网膜病变患者血清中的存在。通过ELISA和Western blot验证，LAMA1抗体阳性与患者视力损伤程度显著相关，提示其作为新型诊断标志物的临床价值。
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如需更具体的文献年份或期刊信息，可进一步补充关键词或限定研究领域!
**Background of LAMA1 Antibody**
The LAMA1 antibody targets laminin subunit alpha-1 (LAMA1), a critical component of laminins—a family of extracellular matrix glycoproteins essential for tissue structure and cellular signaling. LAMA1 is a key subunit of laminin-111 (α1β1γ1), predominantly found in basement membranes during early development. It plays vital roles in cell adhesion, differentiation, and tissue organization by interacting with integrins and other cell surface receptors.
Research on LAMA1 has focused on its involvement in embryonic development, particularly in neural tube formation, muscle integrity, and kidney morphogenesis. Mutations in the *LAMA1* gene are linked to human disorders such as Poretti-Boltshauser syndrome, characterized by brain malformations and retinal defects. In cancer, altered LAMA1 expression is associated with tumor progression and metastasis, reflecting its dual role in both supporting tissue architecture and modulating pathogenic processes.
LAMA1 antibodies are widely used in immunohistochemistry, Western blotting, and immunofluorescence to study protein localization, expression levels, and basement membrane composition in normal and diseased tissues. These tools have advanced understanding of developmental biology, regenerative medicine, and mechanisms underlying genetic or acquired diseases. Commercial LAMA1 antibodies are typically validated for specificity across species, including human, mouse, and rat, ensuring broad applicability in preclinical and clinical research.
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