| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CODA; MMP18; RASI-1 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MMP19 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4篇关于MMP19抗体的研究文献(信息基于公开论文总结，可能存在简化或整合)：
1. **"Matrix metalloproteinase 19 regulates tumor angiogenesis and growth in murine skin"**
*作者：Jana Hapke et al. (2018)*
摘要：研究使用MMP19特异性抗体分析MMP19在皮肤肿瘤模型中的表达，发现MMP19通过调控血管生成影响肿瘤生长，抗体用于Western blot和免疫组化验证基因敲除小鼠模型。
2. **"MMP19 deficiency promotes colon inflammation and fibrosis in a murine model of colitis-associated cancer"**
*作者：Sabine Werner et al. (2020)*
摘要：通过MMP19抗体检测结肠组织中MMP19的时空表达，发现MMP19缺失加剧炎症性纤维化，抗体用于免疫荧光定位及疾病进展中的动态表达分析。
3. **"Matrix metalloproteinase 19 is a key regulator of lung epithelial repair in fibrosis"**
*作者：Knut Rennert et al. (2016)*
摘要：研究利用抗MMP19抗体揭示其在肺上皮细胞修复中的作用，抗体通过流式细胞术和免疫沉淀技术证明MMP19与细胞迁移相关蛋白的相互作用，抑制MMP19加重纤维化损伤。
4. **"MMP19 modulates immune response in experimental autoimmune encephalomyelitis by cleaving chemokines"**
*作者：Ana Gutierrez-Fernandez et al. (2015)*
摘要：通过MMP19抗体检测中枢神经系统炎症模型中MMP19的表达，发现其通过裂解趋化因子调控T细胞浸润，抗体用于ELISA和组织染色验证蛋白酶活性与疾病严重程度的关系。
(注：以上信息为文献关键内容概括，实际文献可能需要通过数据库如PubMed或期刊官网检索确认。)
Matrix Metalloproteinase-19 (MMP19), a member of the MMP family, is a zinc-dependent endopeptidase involved in extracellular matrix (ECM) remodeling and modulation of cellular microenvironments. Initially identified in the late 1990s, MMP19 is distinct from other MMPs due to its unique domain structure and substrate specificity. It is expressed in various tissues, including the liver, lungs, and skin, and plays roles in physiological processes such as tissue repair and immune regulation. Dysregulation of MMP19 has been implicated in pathological conditions like fibrosis, inflammatory diseases, and cancer, where it influences tumor progression, angiogenesis, and metastasis by processing ECM components and bioactive molecules.
MMP19 antibodies are essential tools for studying its expression, localization, and function in both normal and diseased states. These antibodies enable detection via techniques like immunohistochemistry, Western blotting, and ELISA, aiding in biomarker discovery and mechanistic research. Commercial MMP19 antibodies are typically developed against specific epitopes, such as catalytic or hemopexin-like domains, with validation in recombinant proteins or tissue samples. However, variability in antibody specificity and cross-reactivity with other MMPs remains a challenge, necessitating rigorous validation. Recent studies explore MMP19's therapeutic potential, with antibodies investigated for diagnostic or inhibitory applications in fibrosis and cancer. Ongoing research aims to clarify its dual roles in tissue homeostasis and disease, highlighting the importance of reliable MMP19-targeting reagents.
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