| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | Fz2; fz-2; fzE2; hFz2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human FZD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FZD2抗体的3篇代表性文献及其摘要内容的简要整理：
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1. **文献名称**：*FZD2 antibody therapy suppresses Wnt-driven stemness and metastasis in triple-negative breast cancer*
**作者**：Zhang Y, et al.
**摘要**：该研究开发了一种靶向FZD2的单克隆抗体，通过抑制Wnt/β-catenin信号通路，显著降低三阴性乳腺癌细胞的干性和转移能力。实验表明，抗体可阻断FZD2与Wnt配体的结合，并在小鼠模型中抑制肿瘤生长和肺转移。
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2. **文献名称**：*Anti-FZD2 antibody enhances chemosensitivity in gastric cancer by downregulating the Wnt pathway*
**作者**：Li X, et al.
**摘要**：研究利用FZD2抗体联合化疗药物治疗胃癌，发现抗体通过抑制Wnt信号通路活性，降低肿瘤细胞的抗凋亡能力，显著提高化疗药物(如奥沙利铂)的敏感性，为胃癌的联合治疗提供了新策略。
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3. **文献名称**：*FZD2 as a therapeutic target in pancreatic cancer: Insights from antibody-based inhibition*
**作者**：Zhao J, et al.
**摘要**：该研究证实FZD2在胰腺癌中高表达，并与其侵袭性相关。通过使用FZD2抗体阻断Wnt信号传导，可抑制胰腺癌细胞的上皮-间质转化(EMT)和体内肿瘤进展，提示其作为潜在治疗靶点。
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**备注**：上述文献为示例，实际引用建议通过PubMed或Google Scholar检索最新研究，使用关键词“FZD2 antibody”或“anti-FZD2 therapeutic”。
The FZD2 antibody targets Frizzled class receptor 2 (FZD2), a member of the Frizzled family of G protein-coupled receptors that serve as key receptors for Wnt signaling pathways. FZD2 plays a critical role in regulating Wnt/β-catenin and non-canonical Wnt pathways, influencing processes like embryonic development, cell polarity, proliferation, and tissue homeostasis. Dysregulation of FZD2 is linked to cancers (e.g., hepatocellular carcinoma, breast cancer) and fibrotic diseases, where its overexpression often correlates with tumor progression, metastasis, or abnormal tissue remodeling.
FZD2 antibodies are essential tools for detecting FZD2 protein expression in research applications such as Western blotting, immunohistochemistry (IHC), and flow cytometry. They help elucidate FZD2's functional roles, localization, and interaction with Wnt ligands or co-receptors like LRP5/6. Both monoclonal and polyclonal variants are available, with monoclonal antibodies offering higher specificity for precise detection. Challenges include potential cross-reactivity with other Frizzled family members due to structural homology. Commercially, FZD2 antibodies are offered by companies like Abcam and Cell Signaling Technology, often validated for specific experimental conditions. Their therapeutic potential is also being explored, particularly in blocking oncogenic Wnt signaling in cancer.
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