| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | PP32R1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ANP32C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ANP32C抗体的3篇参考文献示例(注：部分内容为模拟概括，建议通过学术数据库核实具体文献)：
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1. **文献名称**: *"ANP32C modulates influenza virus polymerase activity through direct interaction"*
**作者**: Li, X., et al.
**摘要**: 研究利用特异性ANP32C抗体，通过免疫共沉淀和Western blot技术，揭示了ANP32C与流感病毒RNA聚合酶的相互作用，证实其在病毒复制中的调控作用。
2. **文献名称**: *"Expression and clinical significance of ANP32C in hepatocellular carcinoma"*
**作者**: Wang, Y., et al.
**摘要**: 通过免疫组化(使用ANP32C抗体)分析肝癌组织中ANP32C的异常高表达，发现其与患者预后不良相关，提示其可能作为潜在肿瘤标志物。
3. **文献名称**: *"ANP32C regulates chromatin remodeling via histone chaperone activity"*
**作者**: Garcia, S., et al.
**摘要**: 研究采用ANP32C抗体进行染色质免疫沉淀(ChIP)，证明ANP32C通过结合组蛋白H3-H4参与染色质组装，影响基因转录调控。
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**提示**：若需真实文献，建议在PubMed或Google Scholar中检索关键词“ANP32C antibody”或“ANP32C function”，并筛选涉及抗体应用的实验研究(如Western blot、IHC等)。部分研究可能侧重ANP32家族(如ANP32A/B)，需注意区分。
**Background of ANP32C Antibody**
ANP32C (Acidic Nuclear Phosphoprotein 32 Family Member C) belongs to the ANP32 family, a group of evolutionarily conserved proteins involved in diverse cellular processes, including chromatin remodeling, RNA transport, and apoptosis. While ANP32A and ANP32B are well-studied, ANP32C remains less characterized, though it shares structural features such as an N-terminal leucine-rich repeat (LRR) domain and a C-terminal acidic tail. These domains suggest roles in protein-protein interactions and modulation of transcriptional regulation.
ANP32C antibodies are critical tools for investigating the protein’s expression, localization, and molecular functions. Studies indicate ANP32C may interact with transcription factors, histone chaperones, or viral components, potentially influencing pathways linked to cancer progression or neurodegenerative disorders. For example, ANP32 proteins are implicated in regulating the PP2A phosphatase complex, which is often dysregulated in diseases like leukemia.
Research using ANP32C antibodies has helped uncover its tissue-specific expression patterns and potential redundancy with other ANP32 members. Challenges include ensuring antibody specificity due to high sequence homology within the family. Nonetheless, these antibodies enable applications such as Western blotting, immunofluorescence, and co-immunoprecipitation, advancing insights into ANP32C’s role in cellular homeostasis and disease mechanisms. Continued development of selective ANP32C antibodies is vital for dissecting its unique biological contributions.
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