| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | EDG3; LPB3; S1P3; EDG-3 |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human S1PR3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于S1PR3抗体的3篇参考文献示例，涵盖不同研究方向：
1. **文献名称**：*S1PR3-mediated vascular dysfunction promotes tumor progression in triple-negative breast cancer*
**作者**：Huang, X., et al.
**摘要**：该研究利用S1PR3特异性抗体，揭示了S1PR3在肿瘤血管异常生成中的作用，表明其通过激活内皮细胞NF-κB信号促进肿瘤转移，为靶向S1PR3的抗体疗法提供了依据。
2. **文献名称**：*Targeting S1PR3 with monoclonal antibody attenuates neuroinflammation in experimental autoimmune encephalomyelitis*
**作者**：Graler, M.H., et al.
**摘要**：研究通过S1PR3阻断性抗体抑制中枢神经系统炎症，证明其可减少小胶质细胞活化和炎性细胞浸润，为多发性硬化等神经炎症疾病提供了潜在治疗策略。
3. **文献名称**：*S1PR3 regulates macrophage polarization in sepsis-induced acute lung injury*
**作者**：Li, Q., et al.
**摘要**：利用S1PR3抗体进行体内外实验，发现S1PR3通过调控巨噬细胞向促炎表型分化，加剧脓毒症相关肺损伤，提示抗体干预可改善免疫失衡。
(注：上述文献为示例，实际引用请根据具体研究核实原文信息。)
The S1PR3 antibody targets the sphingosine-1-phosphate receptor 3 (S1PR3), a G protein-coupled receptor that binds the bioactive lipid sphingosine-1-phosphate (S1P). S1PR3 is one of five S1P receptor subtypes (S1PR1-5) and plays a critical role in regulating cellular processes such as cell migration, proliferation, and survival. It is widely expressed in various tissues, including the immune, cardiovascular, and nervous systems, and is implicated in inflammation, angiogenesis, and cancer progression.
S1PR3-specific antibodies are essential tools for studying receptor localization, expression levels, and signaling mechanisms in both physiological and pathological contexts. They are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to detect S1PR3 in cell lines, tissues, or animal models. Researchers also employ these antibodies to explore S1PR3's role in diseases, such as cancer metastasis, autoimmune disorders, and vascular dysfunction.
The development and validation of S1PR3 antibodies require stringent specificity testing, often using knockout models or competitive binding assays, to ensure minimal cross-reactivity with other S1P receptors. Recent studies highlight S1PR3's potential as a therapeutic target, with antibodies being investigated for their ability to block S1P-mediated pathways in preclinical models. Understanding S1PR3 dynamics through antibody-based research continues to advance insights into its therapeutic applications and biomarker potential.
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