| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | AC7 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ADCY7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADCY7抗体的3篇参考文献示例(注：文献为虚构示例，仅供参考格式和内容方向)：
1. **文献名称**：*"Characterization of a Novel Anti-ADCY7 Monoclonal Antibody for Cancer Research"*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种高特异性抗ADCY7单克隆抗体，验证了其在Western blot和免疫组化中的适用性，并发现ADCY7在结直肠癌组织中表达显著上调，提示其可能与肿瘤信号通路相关。
2. **文献名称**：*"ADCY7 Antibody-Based Detection in Immune Cell Signaling Pathways"*
**作者**：Lee J, et al.
**摘要**：通过抗ADCY7抗体研究免疫细胞中cAMP信号调控机制，发现ADCY7在T细胞活化中起关键作用，为自身免疫疾病治疗提供了潜在靶点。
3. **文献名称**：*"Validation of Commercial ADCY7 Antibodies for Neuronal cAMP Studies"*
**作者**：Garcia R, et al.
**摘要**：评估了多种市售ADCY7抗体的特异性，发现部分抗体存在交叉反应性，推荐使用克隆号X的抗体用于神经元cAMP相关研究。
**建议**：实际文献请通过PubMed或Google Scholar搜索关键词“ADCY7 antibody”或“ADCY7 immunohistochemistry”获取，并关注近年发表的抗体验证或功能研究论文。
The ADCY7 antibody is a crucial tool for investigating the function and expression of adenylate cyclase 7 (ADCY7), a membrane-associated enzyme encoded by the ADCY7 gene. Belonging to the adenylate cyclase family, ADCY7 catalyzes the conversion of ATP to cyclic AMP (cAMP), a secondary messenger regulating diverse cellular processes, including metabolism, gene expression, and immune responses. ADCY7 is uniquely regulated by G-protein-coupled receptors (GPCRs) and plays roles in immune cell signaling, neuronal function, and cancer progression. Its dysregulation has been linked to inflammatory diseases, neurological disorders, and tumorigenesis, making it a target for therapeutic research.
The ADCY7 antibody is designed to detect endogenous ADCY7 protein in various experimental applications, such as Western blotting (WB), immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. It typically targets specific epitopes within the ADCY7 protein, often validated using knockout controls or siRNA knockdown to ensure specificity. Host species (e.g., rabbit, mouse) and clonality (monoclonal/polyoclonal) vary by commercial source. Researchers rely on this antibody to study ADCY7's tissue distribution, subcellular localization, and expression changes under pathological conditions. Recent studies highlight its utility in exploring ADCY7's role in cancer metastasis, immune cell activation, and cAMP-mediated signaling pathways. Proper validation and optimization of the antibody are critical to avoid cross-reactivity with other adenylate cyclase isoforms (e.g., ADCY1-6. 8-10), ensuring accurate experimental outcomes.
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