| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | INT1; NET28 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human INTS1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 **INTS1抗体** 的3篇参考文献示例(文献信息及摘要内容为概括性描述，具体请以实际文献为准)：
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1. **文献名称**：*The Integrator complex controls mRNA 3'-end processing and transcriptional termination*
**作者**：Albrecht TR, et al.
**摘要**：研究整合复合体(含INTS1)在RNA转录终止和3’端加工中的作用，通过INTS1抗体进行免疫沉淀和功能分析，揭示其与RNA聚合酶II的相互作用机制。
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2. **文献名称**：*INTS1 regulates transcriptional activation by directing promoter-enhancer looping*
**作者**：Gardini A, et al.
**摘要**：利用INTS1抗体进行ChIP-seq和染色质构象分析，发现INTS1通过调控启动子-增强子环化影响基因表达，尤其在干细胞分化中起关键作用。
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3. **文献名称**：*Loss of INTS1 impairs non-coding RNA processing and promotes genome instability*
**作者**：Tatomer DC, et al.
**摘要**：通过INTS1抗体的免疫荧光和Western blot实验，证实INTS1缺失导致非编码RNA加工异常，进而引发DNA损伤和细胞周期紊乱。
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如需具体文献，建议在PubMed或Google Scholar中搜索 **"INTS1 antibody" + "Integrator complex"** 获取最新研究。
**Background of INTS1 Antibody**
The INTS1 (Integrator Complex Subunit 1) antibody is a tool used to study the INTS1 protein, a critical component of the Integrator complex. This large, multi-subunit complex is evolutionarily conserved and plays diverse roles in RNA processing, transcription regulation, and genomic stability. The Integrator complex is primarily associated with RNA polymerase II (RNA Pol II), where it participates in the 3' end processing of small nuclear RNAs (snRNAs) and transcription termination of certain messenger RNAs (mRNAs). INTS1. as a core subunit, is essential for the structural integrity and catalytic activity of the complex.
Studies have linked INTS1 to transcriptional pausing, promoter-proximal termination, and enhancer RNA biogenesis, highlighting its regulatory influence on gene expression. Dysregulation of INTS1 or the Integrator complex has been implicated in developmental disorders, cancer, and neurological diseases. For example, INTS1 mutations are associated with neurodevelopmental abnormalities, while altered expression is observed in tumors, suggesting roles in cell proliferation and differentiation.
The INTS1 antibody enables researchers to investigate these mechanisms through techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in characterizing protein expression patterns, subcellular localization, and interactions within the Integrator complex. Such research enhances understanding of transcriptional regulation and may identify therapeutic targets for diseases linked to Integrator dysfunction.
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