| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | NK1; CD57; HNK1; LEU7; NK-1; GLCATP; GLCUATP |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human B3GAT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于B3GAT1抗体的示例性参考文献(内容基于领域内常见研究方向虚构，仅供参考)：
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1. **文献名称**: *B3GAT1-mediated glycosylation in neural cell adhesion molecule (NCAM) function*
**作者**: Smith A, et al.
**摘要**: 研究利用B3GAT1抗体通过免疫沉淀和Western blot分析，发现B3GAT1对NCAM的糖基化修饰影响神经元突触可塑性，提示其在神经系统发育中的作用。
2. **文献名称**: *B3GAT1 as a potential biomarker in colorectal cancer progression*
**作者**: Chen L, et al.
**摘要**: 通过免疫组化(IHC)结合B3GAT1抗体，发现B3GAT1在结直肠癌组织中高表达，与患者预后不良相关，可能通过调控细胞外基质重塑促进转移。
3. **文献名称**: *Generation and characterization of a monoclonal antibody against human B3GAT1*
**作者**: Tanaka K, et al.
**摘要**: 报道了一种新型B3GAT1单克隆抗体的开发，验证了其在流式细胞术和免疫荧光中的特异性，为研究B3GAT1的亚细胞定位提供了工具。
4. **文献名称**: *B3GAT1 deficiency alters glycosaminoglycan synthesis in a mouse model*
**作者**: Müller R, et al.
**摘要**: 使用B3GAT1抗体检测基因敲除小鼠模型中的蛋白表达缺失，发现B3GAT1缺陷导致硫酸乙酰肝素合成异常，影响骨骼发育。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“B3GAT1 antibody”或“B3GAT1 function”。
**Background of B3GAT1 Antibody**
B3GAT1 (beta-1.3-glucuronyltransferase 1), also known as GlcAT-I, is an enzyme encoded by the *B3GAT1* gene. It plays a critical role in glycosaminoglycan (GAG) biosynthesis by catalyzing the transfer of glucuronic acid to the terminal galactose in the linker region of proteoglycans, a step essential for forming functional GAG chains. These chains are vital for extracellular matrix organization, cell signaling, and cell-matrix interactions.
B3GAT1 antibodies are immunological tools designed to detect and quantify the B3GAT1 protein in research applications. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and flow cytometry to study B3GAT1 expression patterns in various tissues, particularly in the nervous system, where it is implicated in neural development and synaptic plasticity. Dysregulation of B3GAT1 has been associated with neurological disorders, including some forms of epilepsy and intellectual disability, as well as connective tissue abnormalities.
Researchers also utilize B3GAT1 antibodies to explore its role in cancer biology, as altered GAG synthesis may influence tumor progression and metastasis. Additionally, these antibodies aid in characterizing disease models, such as B3GAT1-deficient mice, which exhibit defects in GAG-dependent processes. Understanding B3GAT1's function through antibody-based studies contributes to insights into glycosylation disorders and potential therapeutic targets.
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