| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | BNF1; CHL2; FKSG37 |
| WB Predicted band size | 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CHRDL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CHRDL2抗体的参考文献示例(注：以下为虚构示例，实际文献需通过学术数据库查询)：
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1. **文献名称**：**"CHRDL2 modulates BMP signaling in triple-negative breast cancer"**
**作者**：Johnson M, et al.
**摘要**：本研究利用CHRDL2特异性抗体，通过免疫组化分析发现CHRDL2在乳腺癌组织中的高表达与BMP信号通路抑制相关，提示其可能通过拮抗BMP配体促进肿瘤转移。
2. **文献名称**：**"Developmental expression of CHRDL2 in zebrafish neural crest cells"**
**作者**：Chen L, et al.
**摘要**：通过CHRDL2抗体的免疫荧光染色，揭示了该蛋白在斑马鱼胚胎神经嵴细胞中的动态表达模式，表明其参与颅面骨骼发育及BMP信号的空间调控。
3. **文献名称**：**"CHRDL2 as a potential biomarker in glioblastoma"**
**作者**：Wang Y, et al.
**摘要**：采用CHRDL2抗体进行Western blot和流式细胞术，发现胶质母细胞瘤患者中CHRDL2表达升高，且与肿瘤干细胞特性及化疗耐药性相关。
4. **文献名称**：**"Structural characterization of CHRDL2 and its interaction with BMP4"**
**作者**：Garcia R, et al.
**摘要**：通过免疫共沉淀(使用CHRDL2抗体)和质谱分析，证实CHRDL2直接结合BMP4并抑制其活性，为靶向治疗提供了结构基础。
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如需真实文献，建议在PubMed、Web of Science等平台以“CHRDL2 antibody”为关键词检索，并筛选涉及实验应用的论文。
The CHRDL2 (Chordin-like 2) antibody is a tool used to study the CHRDL2 protein, a member of the Chordin family of secreted extracellular proteins. CHRDL2 functions as a bone morphogenetic protein (BMP) antagonist by binding to BMP ligands (e.g., BMP4. BMP2) and inhibiting their interaction with receptors, thereby modulating BMP signaling pathways. This pathway is critical in embryonic development, tissue homeostasis, and diseases such as cancer and fibrosis. CHRDL2 is expressed in various tissues, including the brain, heart, and skeletal muscle, and has been implicated in neural crest cell differentiation, angiogenesis, and tumor suppression.
Antibodies targeting CHRDL2 enable researchers to investigate its expression patterns, localization, and regulatory roles in both physiological and pathological contexts. For example, studies using CHRDL2 antibodies have revealed its upregulated expression in certain cancers, suggesting potential roles as a biomarker or therapeutic target. These antibodies are widely applied in techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize protein distribution and quantify expression levels in cell lines, animal models, or clinical samples. Recent research also explores CHRDL2's interaction with other signaling molecules (e.g., VEGF) in modulating vascular development. However, challenges remain in standardizing antibody specificity across experimental models, necessitating rigorous validation to ensure reliable data. Overall, CHRDL2 antibodies are vital for unraveling the protein's biological significance and translational potential.
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