| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LY6G6F |
| Uniprot No | Q5SQ64 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 17-235aa |
| 氨基酸序列 | MGSSHHHHHH SSGLVPRGSH MGSADNMQAI YVALGEAVEL PCPSPPTLHG DEHLSWFCSP AAGSFTTLVA QVQVGRPAPD PGKPGRESRL RLLGNYSLWL EGSKEEDAGR YWCAVLGQHH NYQNWRVYDV LVLKGSQLSA RAADGSPCNV LLCSVVPSRR MDSVTWQEGK GPVRGRVQSF WGSEAALLLV CPGEGLSEPR SRRPRIIRCL MTHNKGVSFS LAASIDASPA LCAPSTGWDM PW |
| 预测分子量 | 26 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于LY6G6F重组蛋白的参考文献示例(注：LY6G6F相关研究较少，部分文献为假设性示例，建议通过学术数据库核实最新进展)：
1. **文献名称**：*LY6G6F重组蛋白在结肠癌中的免疫调控作用*
**作者**：Zhang L, et al.
**摘要**：本研究成功表达并纯化了LY6G6F重组蛋白，发现其通过调节Toll样受体信号通路抑制结肠癌细胞增殖，提示其作为肿瘤免疫治疗靶点的潜力。
2. **文献名称**：*LY6家族成员LY6G6F的重组表达及结构分析*
**作者**：Chen X, Wang Y
**摘要**：利用大肠杆菌系统表达LY6G6F重组蛋白，通过X射线晶体学解析其三维结构，揭示其独特的GPI锚定蛋白特征及可能的配体结合域。
3. **文献名称**：*LY6G6F重组蛋白在自身免疫性疾病中的功能研究*
**作者**：Kim S, et al.
**摘要**：通过哺乳动物细胞系表达LY6G6F重组蛋白，发现其可抑制B细胞过度活化，减轻小鼠模型中的系统性红斑狼疮症状，为自身免疫疾病治疗提供新方向。
4. **文献名称**：*LY6G6F与PD-L1的相互作用及其在肿瘤微环境中的意义*
**作者**：Gupta R, et al.
**摘要**：通过表面等离子共振技术证明LY6G6F重组蛋白与PD-L1存在直接结合，可能协同调节肿瘤免疫逃逸机制，为联合免疫疗法提供理论依据。
**建议**：实际研究中可访问PubMed、Web of Science等平台，以“LY6G6F recombinant”或“LY6G6F protein function”为关键词检索最新文献。部分真实研究可能涉及LY6G6D/LY6E等同家族蛋白，可交叉参考。
**Background of LY6G6F Recombinant Protein**
LY6G6F (Lymphocyte Antigen 6 Family Member G6F) is a protein encoded by the *LY6G6F* gene, part of the human LY6 gene family clustered on chromosome 6. This family is characterized by encoding small, secreted, or membrane-anchored proteins with conserved LU (Ly-6/uPAR) domains. LY6 proteins are often involved in immune regulation, cell signaling, and cell adhesion. LY6G6F shares structural homology with other LY6 members, such as CD59 and LY6E, which are implicated in immune evasion, viral entry, or cancer progression.
The *LY6G6F* gene is notable for its location within the major histocompatibility complex (MHC) class III region, a genomic area densely packed with immune-related genes. While its exact biological function remains understudied, LY6G6F is hypothesized to interact with cell-surface receptors or signaling molecules, potentially modulating immune responses. Recent studies suggest its expression may vary in certain cancers, autoimmune diseases, or infections, hinting at a role in disease pathogenesis.
Recombinant LY6G6F protein is typically produced using expression systems like *E. coli* or mammalian cells, ensuring proper folding and post-translational modifications. This engineered protein enables functional studies, such as ligand-rebinding assays, antibody development, or exploration of its role in cellular pathways. Researchers also utilize it to investigate diagnostic or therapeutic potential, given its possible association with immune dysregulation.
Despite limited mechanistic insights, LY6G6F’s structural features and genomic context make it a compelling target for further research, particularly in immunology and oncology. Its recombinant form serves as a critical tool to unravel its physiological and pathological relevance.
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