| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | GB1; GPRC3A; GABABR1; GABBR1-3; dJ271M21.1.1; dJ271M21.1.2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GABBR1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GABBR1抗体的3篇参考文献示例(注：内容为模拟，非真实文献)：
1. **文献名称**：*GABAB receptor subunit 1 (GABBR1) expression in human brain: A comparative study using specific antibodies*
**作者**：Smith A, et al.
**摘要**：本研究通过免疫组织化学和Western blot技术，利用GABBR1特异性抗体分析了该受体在人类不同脑区的分布，发现其在海马和皮层神经元中高表达，并验证了抗体的特异性。
2. **文献名称**：*Role of GABBR1 in synaptic plasticity: Antibody-based localization and functional analysis*
**作者**：Chen L, et al.
**摘要**：文章采用GABBR1抗体结合免疫荧光技术，揭示了该受体在小鼠大脑突触后膜中的定位，并通过基因敲除模型证实抗体特异性，为GABBR1调节突触可塑性的机制提供证据。
3. **文献名称**：*Altered GABBR1 expression in epilepsy: Validation of a novel monoclonal antibody for clinical research*
**作者**：Wang Y, et al.
**摘要**：开发了一种高灵敏度的GABBR1单克隆抗体，并应用于癫痫患者脑组织样本检测，发现GABBR1蛋白表达显著下调，提示其与疾病病理相关。
如需真实文献，建议通过PubMed或Google Scholar搜索关键词“GABBR1 antibody validation”或“GABBR1 immunohistochemistry”获取。
The gamma-aminobutyric acid type B receptor subunit 1 (GABBR1) is a key component of the GABAB receptor, a class of metabotropic G-protein coupled receptors (GPCRs) that mediate the inhibitory effects of GABA, the primary inhibitory neurotransmitter in the central nervous system. Unlike ionotropic GABA receptors, GABAB receptors modulate synaptic activity via second messenger systems, influencing neuronal excitability, neurotransmitter release, and synaptic plasticity. GABBR1 forms a heterodimer with GABBR2. a structural requirement for receptor functionality, enabling coupling to Gi/o proteins to inhibit adenylate cyclase or regulate ion channels.
Antibodies targeting GABBR1 are critical tools for studying its expression, localization, and functional roles in neurological processes. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to map receptor distribution in brain regions such as the hippocampus, cortex, and cerebellum. Research applications include investigating GABBR1's involvement in disorders like epilepsy, anxiety, addiction, and chronic pain, where dysregulated GABAergic signaling is implicated. Additionally, these antibodies aid in exploring receptor trafficking, post-translational modifications, and interactions with ligands or drugs. Commercial GABBR1 antibodies are typically validated for specificity against epitopes in cytoplasmic or extracellular domains, though variability in clonal affinity or cross-reactivity requires careful validation. Understanding GABBR1 dynamics through antibody-based assays contributes to therapeutic development targeting GABAergic pathways for neurological and psychiatric diseases.
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