| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HGAL; GCAT2; GCET2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human GCSAM |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GCSAM抗体的3篇代表性文献概览(注：GCSAM相关研究较为小众，以下为模拟示例，建议通过专业数据库核实具体文献)：
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1. **文献名称**：*GCSAM regulates B cell receptor signaling and germinal center development*
**作者**：Smith A, et al.
**摘要**：该研究揭示了GCSAM蛋白在B细胞受体(BCR)信号通路中的关键作用，通过基因敲除模型发现GCSAM缺失导致生发中心形成缺陷，抗体亲和力成熟受阻，提示其作为治疗B细胞淋巴瘤的潜在靶点。
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2. **文献名称**：*Structural basis of GCSAM-antibody interaction in autoimmune disorders*
**作者**：Li X, et al.
**摘要**：通过冷冻电镜技术解析了GCSAM与自身抗体的复合物结构，阐明了抗原表位结合机制，为开发阻断性抗体治疗类风湿性关节炎等疾病提供了结构基础。
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3. **文献名称**：*GCSAM as a biomarker for antibody-mediated rejection in transplant patients*
**作者**：Wang Y, et al.
**摘要**：临床队列研究表明，血清中抗GCSAM抗体水平与器官移植后抗体介导的排斥反应(AMR)显著相关，可作为无创诊断标志物指导免疫抑制治疗。
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**提示**：若需具体文献，建议在PubMed或Web of Science中以“GCSAM antibody”或“GCSAM therapeutic target”为关键词检索，并筛选近5年高被引论文。
GCSAM (Germinal Center-Associated Signaling and Migration Molecule), also known as CD84-H1 or SLAMF8. is a cell surface protein predominantly expressed in germinal center (GC) B-cells. It belongs to the signaling lymphocytic activation molecule (SLAM) family, which regulates immune cell interactions and signaling. GCSAM plays a critical role in modulating B-cell receptor (BCR) signaling, survival, and differentiation during the GC reaction, a key process in adaptive immunity where B-cells undergo affinity maturation and class-switching to produce high-affinity antibodies. Structurally, GCSAM contains an extracellular immunoglobulin-like domain, a transmembrane region, and cytoplasmic tyrosine-based signaling motifs that recruit adaptor proteins like SAP (SLAM-associated protein) to mediate downstream signaling.
Aberrant GCSAM expression has been linked to B-cell malignancies, particularly aggressive B-cell lymphomas such as diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma. Overexpression of GCSAM in these cancers is associated with enhanced BCR signaling, prolonged cell survival, and chemoresistance, making it a potential therapeutic target. Anti-GCSAM antibodies are being explored for diagnostic and therapeutic applications, including antibody-drug conjugates (ADCs) or bispecific antibodies to selectively target malignant B-cells. Research also investigates its role in autoimmune disorders, where dysregulated GC reactions may contribute to pathogenic autoantibody production. Overall, GCSAM antibodies represent a promising tool for both understanding GC biology and developing targeted therapies in oncology and immunology.
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