| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | K8; HOX2; HOX2H; Hox-2.8 |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human HOXB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOXB2抗体的3篇示例文献(部分信息为合理虚构，仅供参考)：
1. **文献名称**：*HOXB2 Expression in Brainstem Development and Its Transcriptional Regulation*
**作者**：Dickson, G.J., et al. (2005)
**摘要**：通过免疫组化结合HOXB2抗体，研究HOXB2基因在小鼠脑干发育中的动态表达模式，揭示其参与运动神经元分化的调控机制。
2. **文献名称**：*HOXB2 as a Potential Biomarker in Acute Myeloid Leukemia*
**作者**：Takahashi, M., et al. (2012)
**摘要**：利用HOXB2抗体检测白血病细胞系及患者样本，发现HOXB2在AML中异常高表达，且与DNA甲基化修饰异常相关，提示其可作为预后标志物。
3. **文献名称**：*HOXB2 Knockdown Disrupts Cranial Neural Crest Migration in Zebrafish*
**作者**：Smith, R.L., et al. (2008)
**摘要**：通过HOXB2抗体标记斑马鱼胚胎组织，证实HOXB2缺失导致颅神经嵴细胞迁移障碍，阐明其在颅面发育中的关键作用。
4. **文献名称**：*HOXB2-Mediated Epithelial-Mesenchymal Transition in Breast Cancer*
**作者**：Chen, Y., et al. (2016)
**摘要**：采用HOXB2抗体进行免疫荧光染色，发现HOXB2通过激活Wnt/β-catenin通路促进乳腺癌细胞侵袭转移，为靶向治疗提供依据。
(注：以上文献为示例，实际引用时需核实真实来源及内容。)
**Background of HOXB2 Antibody**
The HOXB2 antibody is a tool used to detect HOXB2. a protein encoded by the *HOXB2* gene, part of the homeobox (HOX) gene family. HOX genes are evolutionarily conserved transcription factors critical for embryonic development, particularly in establishing body segment identity along the anterior-posterior axis. HOXB2. located in the HOXB cluster on chromosome 17. plays roles in neural development, hindbrain patterning, and hematopoiesis.
HOXB2 antibodies are typically developed in hosts like rabbits or mice, using immunogens derived from specific regions of the HOXB2 protein. These antibodies enable researchers to study HOXB2's expression patterns, regulatory mechanisms, and interactions via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF).
Research involving HOXB2 antibodies has highlighted its involvement in developmental disorders and cancers. For example, aberrant HOXB2 expression is linked to leukemia, breast cancer, and neuroblastoma, suggesting roles in cell proliferation and differentiation. Such studies underscore its potential as a biomarker or therapeutic target.
HOXB2 antibodies are essential in unraveling the protein's biological functions and its contribution to disease pathways, bridging developmental biology and oncology research. Their specificity and reliability are validated through knockdown controls or peptide blocking to ensure accurate detection in experimental models.
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