| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | TLN; TLCN |
| WB Predicted band size | 97 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ICAM5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ICAM5抗体的示例参考文献(内容为模拟示例，仅供参考)：
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1. **文献名称**: *"ICAM5 Antibody Attenuates Neuroinflammation in Alzheimer’s Disease Models"*
**作者**: Mizuno T, et al.
**摘要**: 该研究利用ICAM5特异性抗体阻断神经元与胶质细胞间的相互作用，发现其可减少β-淀粉样蛋白诱导的小鼠脑内炎症反应，并改善认知功能，提示ICAM5抗体在阿尔茨海默病治疗中的潜力。
2. **文献名称**: *"Targeting ICAM5 with Monoclonal Antibodies Enhances Synaptic Plasticity in Traumatic Brain Injury"*
**作者**: Chen L, et al.
**摘要**: 研究开发了一种靶向ICAM5胞外域的单克隆抗体，实验显示其可促进创伤性脑损伤小鼠模型的突触再生和神经功能恢复，表明ICAM5抗体在神经修复中的应用价值。
3. **文献名称**: *"ICAM5-Specific Antibody Reduces Blood-Brain Barrier Permeability in Ischemic Stroke"*
**作者**: Yamada K, et al.
**摘要**: 通过阻断ICAM5与白细胞整合素的结合，该抗体显著降低了缺血性脑卒中模型中血脑屏障的通透性，减少了脑水肿和神经元损伤，为卒中治疗提供了新策略。
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**注意**：以上文献为示例，实际研究请通过PubMed、Google Scholar等平台检索关键词“ICAM5 antibody”或结合具体研究场景筛选。
The intercellular adhesion molecule 5 (ICAM-5), also known as telencephalin, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Predominantly expressed in neurons of the telencephalon, it localizes to dendritic surfaces and plays critical roles in synaptic plasticity, neuronal migration, and immune interactions within the central nervous system (CNS). Unlike other ICAM family members, ICAM-5 is neuron-specific and regulates cell-cell adhesion through interactions with integrins like LFA-1 (αLβ2) on microglia or leukocytes. Its extracellular domain contains nine immunoglobulin-like domains, which undergo proteolytic cleavage during synaptic maturation or neuroinflammatory conditions, modulating neuronal signaling and immune responses.
ICAM-5 antibodies are essential tools for studying its function in neurodevelopment, neurodegeneration, and neuroinflammatory diseases. Researchers utilize these antibodies in techniques such as Western blotting, immunohistochemistry, and flow cytometry to detect ICAM-5 expression, cleavage, or interactions in cellular and animal models. Dysregulation of ICAM-5 has been implicated in Alzheimer’s disease, stroke, and multiple sclerosis, where its abnormal shedding may exacerbate neuroinflammation or synaptic loss. Therapeutic antibodies targeting ICAM-5 are also under exploration to modulate immune cell infiltration in the CNS or inhibit pathological signaling.
Overall, ICAM-5 antibodies serve both as diagnostic reagents and potential therapeutic agents, bridging neuroscience and immunology research.
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